Status of antioxidant and homocysteine-lowering vitamins related to cardiovascular diseases in hemodialysis patients
Keywords:
Antioxidant, B- vitamin, HemodialysisAbstract
Background and aim: Cardiovascular disease is the major cause of mortality in hemodialysis patients. Oxidative stress and hyperhomocysteinemia may contribute to an increased risk of CVD. Therefore, we assessed the status of antioxidant and homocysteine-lowering vitamins related to cardiovascular disease in hemodialysis patients at Vasei hospital in Sabzevar.
Methods: In this cross-sectional study, we enrolled 75 hemodialysis patients by using census method at Vasei Hospital in Sabzevar (Iran) in 2014. After measuring height and body weight, food intake was assessed by a 24-hour dietary recall questionnaire for at least two days (a non-dialysis and dialysis day), and food frequency was recorded with Nutritionist IV software. Data were analyzed by SPSS version 16, using descriptive statistical tests, one sample t-test and independent samples t-test and p<0.05 was considered statistically significant.
Results: This study was carried out on 75 patients. Mean age and BMI of patients were 49.95±17.22 years and 20.04±3.38 kg/m2, respectively. Intake of all vitamins with the exception of vitamin B12 in hemodialysis patients studied, were less than the recommended dietary allowance (RDA) (p<0.05).
Conclusion: According to the survey, consumption of antioxidants and B-vitamins related to cardiovascular disease was less than RDA in hemodialysis patients.
References
ferences:
Shorecki K, Green J, Brenner BM. Chronic renal failure. In: Kasper D L, Braunwald E, Fauci AS, Hauser
SL, Longo DL, Jameson JL (eds).Harrison’s Principles of Internal Medicine. 16th ed. New York, McGraw- Hill; 2005: 1653-63
Ziyadeh FN. Approach to the patient with chronic renal failure. In: Humes HD (ed). Kelley’s Textbook of
Internal Medicine. Philadelphia: Williams & Wilkins; 2000: 1133-4
Schulman J, Himmelfarb J. Hemodialysis. In: Brener BM. Brener and Rector,s the kidney.7 ed.
Philadelphia ; W.B Saunders; 2004: 2563-4
Islam KN, OByrne D, Devaraj S, Palmer B, Grundy SM, Jialal I. Alpha- tocopherol supplementation
decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy. Atherosclerosis;
; 150: 217-24, doi: 10.1016/S0021-9150(99)00410-4, PMID: 10781654
Singh AK, Brenner BM. Dialysis in the treatment of renal failure. In: Kasper DL, Braunwald E, Fauci AS,
Hauser SL, Longo DL, Jameson JL (eds). Harrison’s Principles of Internal Medicine. 16th ed. New York:
McGraw-Hill; 2005: 1663-7. PMID: 10781654
Jungers P, Khoa TN, Massy ZA, Zingraff J, Labrunie M, Descamps-Latscha B, et al. Incidence of
atherosclerotic arterial occlusive accidents in predialysis and dialysis patient: a multicentric study in the IIe
de france district. Nephrol Dial Transplant. 1999; 14: 898-902. doi: 10.1093/ndt/14.4.898, PMid: 10328467
Nakamura S, Sasaki O, Nakahama H, Inenaga T, Kawano Y. Clinical characterictics and survival in end- stage renal disease patients with atherosclerosis obliterans. Am J Nephrol. 2002; 22: 422-428. DOI:
1159/000065267
Ritz E, Bommer J. Cardiovascular problems on hemodialysis: current deficits and potential improvement.
Clin J Am Soc Nephrol. 2009; 4( Suppl 1): 571-8. DOI: 10.2215/CJN.01960309
Montazerifar F, Hashemi M, Karajibaniand M, Dikshit M. Natural antioxidants and oxidative stress
markers in hemodialysis patients. Hong Kong Journal of Nephrology. 2010; 12(2): 57-61,
DOI:10.1016/S1561-5413(10)60013-0
Jackson P, Loughrey C.M, Lightbody J.H, McNamee P.T, Young IS. Effect of hemodialysis on total
antioxidants in patients with chronic renal failure. Clin Chem. 1995; 41(8): 1135-8. PMID: 7628087
Manns B, Hyndman E, Burgwss E, Parsons H, Schaefer J, Snyder F, etal. Oral vitamin B12 and high-dose
folic acid in hemodialysis patients with hyper-homocysteinemia. Kidney International. 2001; 59(3), 1103–
DOI: 10.1046/j.1523-1755.2001.0590031103.x
Righetti M. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis
patients. Clin Chem Lab Med. 2007; 45(12): 1586-1589. DOI: 10.1515/CCLM.2007.335
Ghaffarpour M, Houshiar-Rad A, Kianfar H. The manual for householdmeasures, cooking yields factors
and edible portion of foods. Tehran, Keshaverzi Press. 1999; 1–46 (in Persian)
Mahan, K. and S. Escott-Stump, Krauses food, nutrition diet therapy. 11 ed, Saunders Company,
Philadelphia,: 2004: 366-7
Stenvinkel P, Yeun JY. Role of inflammation in malnutrition and atherosclerosis in chronic renal
failure. In: Kopple JD, Massry SG (eds). Kopple & Massry 's Nutritional Management of Renal Disease.
nd ed. Philadelphia: Lippincott Williams & Wilkins; 2004: 199-212.
Loughrey CM, Young IS, McEneny J, McDowell IFW, McMaster C, McNamee PT, et al. Oxidation of
low-density lipoproteins in patients on regular haemodialysis. Atherosclerosis. 1994; 110: 185-93.
PMID:7848368, doi: 10.1016/0021-9150(94)90203-8
Stenvinkel P. Inflammation in end-stage renal failure: could it be treated? Nephrol Dial Transplant. 2002;
[Suppl 8]: 33-8. PMID: 12147775, doi: 10.1093/ndt/17.suppl_8.33
Deicher R, Horl WH. Vitamin C in chronic kidney disease and hemodialtsis patients. Kidney Blood Press
Res. 2003; 26: 100-6. DOI:10.1159/000070991
Abdollahzad H, Eghtesadi S, Nourmohammadi I, Khadem-Ansari M, Nejad-Gashti H, Esmaillzadeh A.
Effect of vitamin C supplementation on oxidative stress and lipid profiles in hemodialysis patients. Int J
Vitam Nutr Res. 2009; 79(5-6): 281-7. DOI: 10.1024/0300-9831.79.56.281
Chao J.C, Yuan M.D, Chen PY, Chien S.W. Vitamin C and E supplements improve the impaired
antioxidant status and decrease plasma lipid peroxides in hemodialysis patients. The Journal of Nutritional
Biochemistry. 2002; 13(11): 653-63. PMID: 12550062, doi: 10.1016/S0955-2863(02)00209-7
Galli F, Varga Z, Balla J, Ferraro B, Canestrari F, Floridi A, Kakuk G, Buoncristiani U. Vitamin E, lipid
profile, and peroxidation in hemodialysis patients. Kidney Int Suppl. 2001; 59(78): 148-54.
doi:10.1046/j.1523-1755.2001.59780148.x
Wanner C, Zimmermann J, Quaschning T, Galle J. Inflammation, dyslipidemia and vascular risk factors in
hemodialysis patients. Kidney Int Suppl. 1997; 62: S53-5. PMID: 9350681
Wanner C. Altered lipid metabolism and serum lipids in renal disease and renal failure. In: Kopple JD,
Massry SG, editors. Kopple and Massry's Nutritional Management of Renal Disease. 2nd ed. Philadelphia:
Lippincott Williams & Wilkins; 2004: 42-55.
Sutherland WHF, Walker RJ, Ball MJ, Stapley SA, Robertson MC. Oxidation of low-density
lipoproteinsfrom patients with renal failure or renal transplants. Kidney Int. 1995; 48: 227-36. PMID:
Jeff S. Coombes, Robert G. Antioxidant therapy in hemodialysis patients: a systematic review. Kidney Int.
; 81(3): 233-246. DOI: 10.1038/ki.2011.341
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