Depression, anxiety and quality of life in stroke survivors and their family caregivers

A pilot study using an actor/partner interdependence model

Authors

  • Syed Tajuddin Syed Hassan Ph.D., in Ecology/Statistical Entomology, Professor, Department of Nursing and Rehabilitation, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor D.E., Malaysia

Keywords:

Malaysia, Quality of life, Stroke, Anxiety, Depression, Caregivers

Abstract

Background: Depression and anxiety are common in stroke survivors as well as their family caregivers. However, it is not known whether each person’s emotional distress contributes to their partner’s quality of life (QOL). 

Objective: This study aimed to examine the effect of depression and anxiety on QOL in stroke survivor-caregiver dyads using dyadic analysis technique - the Actor-Partner Interdependence Model (APIM).  

Methods: This was a cross-sectional pilot study with a total of 30 participating dyads (30 stroke survivors and 30 family caregivers) from Hospital Rehabilitasi Cheras, Kuala Lumpur, Malaysia. This pilot study was conducted over a period of 3 months, between December 2014 and February 2015. Depression and anxiety were assessed using the Hospital Anxiety and Depression Scale (HADS). QOL was assessed using the Short Form-12 Health Survey (SF-12). All analyses were carried out using IBM SPSS version 22. Dyadic data were analysed using multilevel modelling (MLM).

Results: Depression was uniquely associated with an individual’s own QOL. Survivors and caregivers with higher depression had poorer physical component summary (PCS) scores and mental component summary (MCS) scores. Stroke survivor’s depression exerted a significant actor effect on their PCS (b=-1.42, p=0.001) and MCS (b=-1.52, p<0.001). Caregiver’s depression exerted a significant actor effect on their PCS (b=-2.53, p<0.001) and MCS (b=-1.51, p=0.004). Caregivers’ anxiety negatively influenced their own MCS (b=-0.58, p=0.031). Furthermore, depression exerted a significant partner effect on PCS in stroke survivors (b=-1.19, p=0.003). Caregivers’ depression was also related to their stroke survivors’ poorer QOL, particularly PCS.

Conclusion: The findings suggest that depression affects the QOL of both stroke survivors and caregivers, not only emotionally but also physically. This dyadic study also has evidence pointing to depression in caregivers and its association with stroke survivors’ physical QOL.

References

Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and

regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010.

Lancet. 2014; 383(9913): 245-54. doi: 10.1016/S0140-6736(13)61953-4. PMID: 24449944, PMCID:

PMC4181600.

Scherbakov N, Doehner W. Sarcopenia in stroke-facts and numbers on muscle loss accounting for

disability after stroke. J Cachexia Sarcopenia Muscle. 2011; 2(1): 5-8. doi: 10.1007/s13539-011-0024-8.

PMID: 21475676, PMCID: PMC3063875.

Aziz ZA, Lee YY, Ngah BA, Sidek NN, Looi I, Hanip MR, et al. Acute Stroke Registry Malaysia, 2010- 2014: Results from the National Neurology Registry. J Stroke Cerebrovasc Dis. 2015; 24(12): 2701-9. doi:

1016/j.jstrokecerebrovasdis.2015.07.025. PMID: 26338106.

Krishnamoorthy M. Killer stroke: Six Malaysians hit every hour. The Star. 2007. Nation. Available from:

http://www.thestar.com.my/story/?file=%2F2007%2F4%2F24%2Fnation%2F17524877.

Ministry of Health M. Health Facts 2009. Malaysia: Health Information Centre, Planning and Development

Division; 2010.

Balhara YP, Verma R, Sharma S, Mathur S. A study of predictors of anxiety and depression among stroke

patient-caregivers. J Midlife Health. 2012; 3(1): 31-5. doi: 10.4103/0976-7800.98815. PMID: 22923977,

PMCID: PMC3425146.

Hackett ML, Yapa C, Parag V, Anderson CS. Frequency of depression after stroke: a systematic review of

observational studies. Stroke. 2005; 36(6): 1330-40. doi: 10.1161/01.str.0000165928.19135.35. PMID:

Campbell Burton CA, Murray J, Holmes J, Astin F, Greenwood D, Knapp P. Frequency of anxiety after

stroke: a systematic review and meta-analysis of observational studies. Int J Stroke. 2013; 8(7): 545-59.

doi: 10.1111/j.1747-4949.2012.00906.x. PMID: 23013268.

Tang WK, Lau CG, Mok V, Ungvari GS, Wong KS. Impact of anxiety on health-related quality of life after

stroke: a cross-sectional study. Arch Phys Med Rehabil. 2013; 94(12): 2535-41. doi:

1016/j.apmr.2013.07.012. PMID: 23911556.

Carod-Artal FJ, Egido JA. Quality of life after stroke: the importance of a good recovery. Cerebrovasc Dis.

; 27 Suppl 1: 204-14. doi: 10.1159/000200461. PMID: 19342853.

Godwin KM, Ostwald SK, Cron SG, Wasserman J. Long-term health-related quality of life of stroke

survivors and their spousal caregivers. J Neurosci Nurs. 2013; 45(3): 147-54. doi:

1097/JNN.0b013e31828a410b. PMID: 23558977, PMCID: PMC3646534.

Morimoto T, Schreiner AS, Asano H. Caregiver burden and health-related quality of life among Japanese

stroke caregivers. Age Ageing. 2003; 32(2): 218-23. doi: 10.1093/ageing/32.2.218. PMID: 12615568.

McCarthy MJ, Lyons KS, Powers LE. Expanding poststroke depression research: movement toward a

dyadic perspective. Top Stroke Rehabil. 2011; 18(5): 450-60. doi: 10.1310/tsr1805-450. PMID: 22082696.

McCarthy MJ, Lyons KS, Powers LE. Relational factors associated with depressive symptoms among

stroke survivor-spouse dyads. J Fam Soc Work. 2012; 15(4): 303-20. doi: 10.1080/10522158.2012.696230.

Pucciarelli G, Vellone E, Savini S, Simeone S, Ausili D, Alvaro R, et al. Roles of Changing Physical

Function and Caregiver Burden on Quality of Life in Stroke: A Longitudinal Dyadic Analysis. Stroke.

; 48(3): 733-9. doi: 10.1161/strokeaha.116.014989. PMID: 28196939.

Fatoye FO, Komolafe MA, Adewuya AO, Fatoye GK. Emotional distress and self-reported quality of life

among primary caregivers of stroke survivors in Nigeria. East Afr Med J. 2006; 83(5): 271-9. doi:

4314/eamj.v83i5.9433. PMID: 16866222.

Kenny DA, Kashy DA, Cook WL. Dyadic data analysis. New York: Guilford Press; 2006: 458.

Zarina Z, Zahiruddin O, AH CW. Validation of Malay mini mental state examination. Malaysian Journal of

Psychiatry. 2007; 16(1): 16-9.

Pickard AS, Johnson JA, Penn A, Lau F, Noseworthy T. Replicability of SF-36 summary scores by the SF- 12 in stroke patients. Stroke. 1999; 30(6): 1213-7. doi: 10.1161/01.STR.30.6.1213. PMID: 10356102.

Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and

preliminary tests of reliability and validity. Med Care. 1996; 34(3): 220-33. doi: 10.1097/00005650- 199603000-00003. PMID: 8628042.

Noor NM, Aziz AA. Validity and reliability of the Malay version of 12-item short form health survey

among postpartum mothers. Malaysian Journal of Public Health Medicine. 2014; 14(2): 56-66.

Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale.

An updated literature review. J Psychosom Res. 2002; 52(2): 69-77. doi: 10.1016/S0022-3999(01)00296-3.

PMID: 11832252.

Yusoff N, Low WY, Yip CH. Psychometric properties of the Malay Version of the hospital anxiety and

depression scale: a study of husbands of breast cancer patients in Kuala Lumpur, Malaysia. Asian Pac J

Cancer Prev. 2011; 12(4): 915-7. PMID: 21790225.

Quinn TJ, Langhorne P, Stott DJ. Barthel index for stroke trials: development, properties, and application.

Stroke. 2011; 42(4): 1146-51. doi: 10.1161/strokeaha.110.598540. PMID: 21372310.

Chung ML, Moser DK, Lennie TA, Rayens MK. The effects of depressive symptoms and anxiety on

quality of life in patients with heart failure and their spouses: testing dyadic dynamics using Actor-Partner

Interdependence Model. J Psychosom Res. 2009; 67(1): 29-35. doi: 10.1016/j.jpsychores.2009.01.009.

PMID: 19539816, PMCID: PMC2732117.

Hatfield E, Cacioppo JT, Rapson RL. Emotional contagion. Current directions in psychological science.

; 2(3): 96-100. doi: 10.1111/1467-8721.ep10770953.

Goodman CR, Shippy RA. Is it contagious? Affect similarity among spouses. Aging Ment Health. 2002;

(3): 266-74. doi: 10.1080/13607860220142431. PMID: 12217095.

Bluvol A, Ford-Gilboe M. Hope, health work and quality of life in families of stroke survivors. J Adv Nurs.

; 48(4): 322-32. doi: 10.1111/j.1365-2648.2004.03004.x. PMID: 15500526.

Van Puymbroeck M, Rittman MR. Quality-of-life predictors for caregivers at 1 and 6 months poststroke:

Results of path analyses. J Rehabil Res Dev. 2005; 42(6): 747-60. doi: 10.1682/JRRD.2005.01.0025.

PMID: 16680612.

Saban KL, Sherwood PR, DeVon HA, Hynes DM. Measures of psychological stress and physical health in

family caregivers of stroke survivors: a literature review. J Neurosci Nurs. 2010; 42(3): 128-38. doi:

1097/jnn.0b013e3181d4a3ee. PMID: 20550072.

McCullagh E, Brigstocke G, Donaldson N, Kalra L. Determinants of caregiving burden and quality of life

in caregivers of stroke patients. Stroke. 2005; 36(10): 2181-6. doi: 10.1161/01.STR.0000181755.23914.53.

PMID: 16151029.

Haley WE, Roth DL, Hovater M, Clay OJ. Long-term impact of stroke on family caregiver well-being: a

population-based case-control study. Neurology. 2015; 84(13): 1323-9. doi:

1212/wnl.0000000000001418. PMID: 25740862, PMCID: PMC4388745.

Kamel AA, Bond AE, Froelicher ES. Depression and caregiver burden experienced by caregivers of

Jordanian patients with stroke. Int J Nurs Pract. 2012; 18(2): 147-54. doi: 10.1111/j.1440- 172X.2012.02011.x. PMID: 22435978.

Lau CG, Tang WK, Wong KS, Mok V, Ungvari GS. Predictors of the depressive symptomatology of the

family caregivers of Chinese stroke patients in Hong Kong. J Psychiatr Ment Health Nurs. 2012; 19(4):

-93. doi: 10.1111/j.1365-2850.2011.01782.x. PMID: 22070345.

Draper P, Brocklehurst H. The impact of stroke on the well-being of the patient's spouse: an exploratory

study. J Clin Nurs. 2007; 16(2): 264-71. doi: 10.1111/j.1365-2702.2006.01575.x. PMID: 17239061.

Godwin KM, Swank PR, Vaeth P, Ostwald SK. The longitudinal and dyadic effects of mutuality on

perceived stress for stroke survivors and their spousal caregivers. Aging Ment Health. 2013; 17(4): 423-31.

doi: 10.1080/13607863.2012.756457. PMID: 23323629, PMCID: PMC3646563.

Published

2022-01-18

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