Epilepsy as a health problem among school children in Turaif, Northern Saudi Arabia, 2017
Keywords:
Prevalence, Epilepsy, Turaif, Northern border, Saudi ArabiaAbstract
Background: Epilepsy is the most common serious neurological disorder and is one of the world’s most prevalent non-communicable diseases. There are no recently published data on the prevalence of epilepsy in school children in Northern Saudi Arabia.
Objective: This study was conducted to determine the prevalence of epilepsy and to show some of its risk factors in school children and adolescents (6-18 years) in Turaif city, Northern Saudi Arabia.
Methods: This, population-based, cross-sectional study was conducted in Turaif city, over a 6-month period, from July 2016 to January 2017. It included pupils aged 6 to18 years in all primary, preparatory and secondary schools in Turaif city. Multi-stage sampling was employed. A designated structured questionnaire was completed for each patient and included the patient’s history, clinical examination, investigations and medications. Data were analyzed by SPSS version 16, using Chi-Squared test and descriptive statistics.
Results: Out of 1,230 children, 66 (5.5%) had epilepsy; 68.2% of them were males and 31.8% females (p=0.000). Consanguinity between parents plays a significant role where 59.1% of cases had parents who were cousins (p=0.000). Family history also had a significant effect as 68.2% of cases had epilepsy cases in their families (p=0.000).
Conclusion: Epilepsy prevalence among school children (6-18 years) in Turaif city is higher in males than females. Consanguinity and positive family history are important factors. Decision makers must take effective steps to limit the causes and risk factors of the problem.
References
Chang BS, Lowenstein DH. Epilepsy. N Engl J Med. 2003; 349(13): 1257–66. doi:
1056/NEJMra022308. PMID: 14507951.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a
practical clinical definition of epilepsy. Epilepsia. 2014; 55(4): 475-82. doi: 10.1111/epi.12550. PMID:
Hauser WA, Banerjee PE. Epidemiology of epilepsy in children. Pediatric epilepsy. 3rd ed. New York;
Demos Medical Publishing; 2008: 147–64.
Yeni, SN. Epilepsi İnsidansı, Prevalansı ve Risk Faktörleri. Epilepsi. İstanbul: Nobel Tıp Kitapevleri; 2008:
–73.
Noebels J, Avoli M, Rogawski M, Olsen R, Delgado-Escueta A. Jasper's Basic Mechanisms of the
Epilepsies. Oxford University Press. 2012: 466-70. ISBN 9780199746545.
Epilepsy, Fact sheet. WHO. 2016.
Hammer GD, McPhee SJ. Pathophysiology of disease: an introduction to clinical medicine. 6th ed. New
York: McGraw-Hill Medical; 2010. ISBN 978-0-07-162167-0.
Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction.
Nat Rev Neurosci. 2013; 14 (5): 337–49. doi: 10.1038/nrn3482. PMID: 23595016, PMCID: PMC3982383.
Le Van Quyen M, Navarro V, Martinerie J, Baulac M, Varela FJ. Toward a Neurodynamical
Understanding of Ictogenesis. Epilepsia. 2003; 44(Suppl 12): 30–43. doi: 10.1111/j.0013- 9580.2003.12007.x. PMID: 14641559.
Lopes da Silva F, Blanes W, Kalitzin SN, Parra J, Suffczynski P, Velis DN. Epilepsies as Dynamical
Diseases of Brain Systems: Basic Models of the Transition Between Normal and Epileptic Activity.
Epilepsia. 2003; 44(Suppl 12): 72–83. doi: 10.1111/j.0013-9580.2003.12005.x. PMID: 14641563.
Berkovic SF, Mulley JC, Scheffer IE, Petrou S. Human epilepsies: interaction of genetic and acquired
factors. Trends Neurosci. 2006; 29(7): 391–7. doi: 10.1016/j.tins.2006.05.009. PMID: 16769131.
National Clinical Guideline Centre. The Epilepsies: The diagnosis and management of the epilepsies in
adults and children in primary and secondary care. National Institute for Health and Clinical Excellence.
: 21–8.
Epilepsy, Fact Sheets. WHO. 2012.
ILAE Commission Report. The epidemiology of the epilepsies: future directions. International League
Against Epilepsy. Epilepsia. 1997; 38: 614–8. doi: 10.1111/j.1528-1157.1997.tb01148.x. PMID: 9184609.
Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and Prognosis,
International League Against Epilepsy. Epilepsia. 1993; 34(4): 592–6. doi: 10.1111/j.1528- 1157.1993.tb00433.x. PMID: 8330566.
Huseyinoglu N, Ozben S, Arhan E, Palanci Y, Gunes N. Prevalence and risk factors of epilepsy among
school children in eastern Turkey. Pediatr Neurol. 2012; 47(1): 13-8. doi:
1016/j.pediatrneurol.2012.04.007. PMID: 22704010.
Canpolat M, Kumandas S, Poyrazoglu HG, Gumus H, Elmali F, Per H. Prevalence and risk factors of
epilepsy among school children in Kayseri City Center, an urban area in Central Anatolia, Turkey. Seizure.
; 23(9): 708-16. doi: 10.1016/j.seizure.2014.05.012. PMID: 24939524.
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology
and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification
and terminology, 2005–2009. Epilepsia. 2010; 51: 676–85. doi: 10.1111/j.1528-1167.2010.02522.x. PMID:
The Global Campaign against Epilepsy. Geneva: World Health Organization: 2000.
Scott RA, Lhatoo SD, Sander JW. The treatment of epilepsy in developing countries: where do we go from
here? Bull World Health Organ. 2001; 79(4): 344-51. PMID: 11357214, PMCID: PMC2566404.
Brodie MJ, Elder AT, Kwan P. Epilepsy in later life. Lancet neurology. 2009; 8(11): 1019-30. doi:
1016/S1474-4422(09)70240-6. PMID: 19800848.
Holmes GL, Browne TR. Handbook of epilepsy. 4th ed. Philadelphia: Lippincott Williams & Wilkins;
: 7. ISBN 978-0-7817-7397-3.
Newton CR, Garcia HH. Epilepsy in poor regions of the world. Lancet. 2012; 380(9848): 1193-201. doi:
1016/S0140-6736(12)61381-6.
Bertolote JM. Epilepsy as a public health problem. Role of the World Health Organization and of the
cooperation between WHO and non-governmental organizations. Trop Geogr Med. 1994; 46(3 Suppl):
S28-30. PMID: 7974766.
Aziz H, Güvener A, Akhtar SW, Hasan KZ. Comparative epidemiology of epilepsy in Pakistan and
Turkey: population-based studies using identical protocols. Epilepsia. 1997; 38: 716–22. doi:
1111/j.1528-1157.1997.tb01242.x. PMID: 9186255.
Gourie-Devi M, Satischandra P, Gururaj G. Report of national workshop on public health aspects of
epilepsy for senior health personnel of state health departments in India. Annals of Indian Academy of
Neurology. 1999; 2: 43–8.
al Rajeh S, Bademosi O, Ismail H, Awada A, Dawodu A, al-Freihi H, et al. A Community Survey of
Neurological Disorders in Saudi Arabia: The Thugbah Study. Neuroepidemiology. 1993; 12(3): 164–78.
doi: 10.1159/000110316. PMID: 8272177.
Aziz H, Ali SM, Frances P, Khan MI, Hasan KZ. Epilepsy in Pakistan. A population based epidemiologic
study. Epilepsia. 1994; 35: 950–8. doi: 10.1111/j.1528-1157.1994.tb02539.x. PMID: 7925166.
Placencia M, Shorvon SD, Paredes V, Bimos C, Sander JW, Suarez J. Epileptic seizures in an Andean
region of Ecuador. Incidence prevalence and regional variations. Brain. 1992; 115: 771–82. doi:
1093/brain/115.3.771. PMID: 1628201.
Haerer AF, Anderson DW, Schoenberg BS. Prevalence and clinical features of epilepsy in a biracial United
States population. Epilepsia. 1986; 27: 66–75. doi: 10.1111/j.1528-1157.1986.tb03503.x. PMID: 3948820.
Hauser WA, Kurland LT. The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967.
Epilepsia. 1975; 16: 1–66. doi: 10.1111/j.1528-1157.1975.tb04721.x. PMID: 804401.
Li SC, Schoenberg BS, Wang CC, Cheng XM, Zhou SS, Bolis CL. Epidemiology of epilepsy in urban
areas of the Peoples’ Republic of China. Epilepsia. 1985; 26: 391–4. doi: 10.1111/j.1528- 1157.1985.tb05669.x. PMID: 4043008.
Bharucha NE, Bharucha EP, Bharucha AE, Bhise AV, Schoenberg BS. Prevalence of epilepsy in the Parsi
community of Bombay. Epilepsia. 1988; 29: 111–115. doi: 10.1111/j.1528-1157.1988.tb04405.x. PMID:
Attia-Romdhane N, Mrabet A, Ben Hamida M. Prevalence of epilepsy in Kelibia, Tunisia. Epilepsia. 1993;
: 1028–32. doi: 10.1111/j.1528-1157.1993.tb02129.x. PMID: 8243352.
Annegers JF, Grabow JD, Groover RV, Laws ER Jr, Elveback LR, Kurland LT. Seizures after head trauma:
a population study. Neurology. 1980; 30: 683–9. doi: 10.1212/WNL.30.7.683. PMID: 7190235.
Hauser WA. The Prevalence and Incidence of Convulsive Disorders in Children. Epilepsia. 1994; 35 Suppl
: S1-6. PMID: 8275976.
Ae-Ngibise KA, Akpalu B, Ngugi A, Akpalu A, Agbokey F, Adjei P, et al. Prevalence and risk factors for
Active Convulsive Epilepsy in Kintampo, Ghana. Pan Afr Med J. 2015; 21: 29. doi:
11604/pamj.2015.21.29.6084. PMID: 26401223, PMCID: PMC4561141.
Prischich F, De Rinaldis M, Bruno F, Egeo G, Santori C, Zappaterreno A, et al. High prevalence of
epilepsy in a village in the Littoral Province of Cameroon. Epilepsy Res. 2008; 82(2-3): 200-10. doi:
1016/j.eplepsyres.2008.09.004. PMID: 18976884.
Sangrador CO, Palencia Luaces R. Study of the prevalence of epilepsy among school children in
Valladolid, Spain. Epilepsia. 1991; 32: 791–797. doi: 10.1111/j.1528-1157.1991.tb05535.x.
Forsgren, L, Beghi, E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe – a systematic review.
Eur J Neurol. 2005; 12: 245–53. doi: 10.1111/j.1468-1331.2004.00992.x. PMID: 15804240.
Berkovic SF, Howell RA, Hay DA, Hoppaer JL. Epilepsies in twins: genetics of the major epilepsy
syndromes. Ann Neurol. 1998; 43: 435–45. doi: 10.1002/ana.410430405. PMID: 9546323.
Vadlamudi L, Andermann E, Lombroso CT, Schachter SC, Milne RL, Hopper JL, et al. Epilepsy in twins:
insights from unique historical data of William Lennox. Neurology. 2004; 62: 1127-33. doi:
1212/01.WNL.0000118201.89498.48. PMID: 15079012.
Ottman R, Lee JH, Risch N, Hauser WA, Susser M. Clinical indicators of genetic susceptibility to
epilepsy. Epilepsia. 1996; 37: 353–61. doi: 10.1111/j.1528-1157.1996.tb00571.x. PMID: 8603640
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