Deep venous thrombosis among diabetic patients in King Abdulaziz University (KAU) Hospital, Jeddah, Kingdom of Saudi Arabia
Keywords:
DVT, Diabetes, Risk factorAbstract
Background: Deep venous thrombosis (DVT) is a major cause of morbidity and mortality among hospitalized patients worldwide and, simultaneously, the most preventable. Studies revealed several risk factors of deep venous thrombosis in hospitalized patients.
Objective: to identify frequency and factors associated with occurrence of deep venous thrombosis among diabetic patients referred to King Abdulaziz University (KAU) Hospital, Jeddah, Kingdom of Saudi Arabia.
Methods: This cross-sectional hospital-based study was conducted from June to December, 2016. All diabetic patients referred to the hospital departments and who were suspected to have deep venous thrombosis (DVT) and subjected to Doppler examination were included in the study. A questionnaire was designed to obtain data about deep venous thrombosis frequency among participants and factors associated with the development of deep venous thrombosis among them. Data was collected through face to face interviews with patients included in the study. We used SPSS version 16 for data analysis through descriptive statistics and Chi-square test.
Results: DVT was detected in 14.7 % of the examined patients. There were significant and positive associations between age and DVT (X2=10.13, p=0.03) and between ischemic heart disease and DVT (X2=1.628, p=0.043) with the development of deep venous thrombosis among the studied patients. On the other hand, gender, other comorbidities, history of previous DVT, being bed ridden and using orthopedic casting were not significantly associated with the occurrence of deep venous thrombosis among the participants.
Conclusion: DVT development rate among the participants was 14.7 %. Aging was significantly associated with DVT occurrence. Most of the studied factors and comorbidities had no significant role in DVT development among participants and only ischemic heart disease was significantly associated with DVT development.
References
Okuhara A, Navarro TP, Procópio RJ, Bernardes RDC, Oliveira LDCC, Nishiyama MP. Incidence of deep
vein thrombosis and quality of venous thromboembolism prophylaxis. Rev Col Bras Cir. 2014; 41(1): 02-6.
doi: 10.1590/S0100-69912014000100002. PMID: 24770766.
Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al. Prevention of venous
thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th
Edition). Chest journal. 2008; 133(6_suppl): 381S-453S. doi: 10.1378/chest.08-0656. PMID: 18574271.
García-Raso A, Sillero PL. Elevated body fat is a risk factor for venous thromboembolism and thrombotic
complications. Epidemiology Reports. 2014; 2(1): 3. doi: 10.7243/2054-9911-2-3.
Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, et al. Venous thromboembolism
(VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost.
; 98(4): 756-64. PMID: 17938798.
Caprini JA, Tapson VF, Hyers TM, Waldo AL, Wittkowsky AK, Friedman R, et al. Treatment of venous
thromboembolism: adherence to guidelines and impact of physician knowledge, attitudes, and beliefs. J
Vasc Surg. 2005; 42(4): 726-33. doi: 10.1016/j.jvs.2005.05.053. PMID: 16242561.
Arnold DM, Kahn SR, Shrier I. Missed opportunities for prevention of venous thromboembolism: an
evaluation of the use of thromboprophylaxis guidelines. Chest. 2001; 120(6): 1964-71. doi:
1378/chest.120.6.1964. PMID: 11742929.
Awolesi D, Naidoo M, Cassimjee MH. The profile and frequency of known risk factors or comorbidities
for deep vein thrombosis in an urban district hospital in KwaZulu-Natal. Southern African Journal of HIV
Medicine. 2016; 17(1): 1-5. doi: 10.4102/sajhivmed.v17i1.425.
Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, et al. Prevention of venous
thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest.
; 126(3_suppl): 338S-400S. doi: 10.1378/chest.126.3_suppl.338S. PMID: 15383478.
Heit JA, Leibson CL, Ashrani AA, Petterson TM, Bailey KR, Melton LJ. Is diabetes mellitus an
independent risk factor for venous thromboembolism? Arterioscler Thromb Vasc Biol. 2009; 29(9): 1399- 405. doi: 10.1161/ATVBAHA.109.189290. PMID: 19542020, PMCID: PMC2735343.
Petrauskiene V, Falk M, Waernbaum I, Norberg M, Eriksson JW. The risk of venous thromboembolism is
markedly elevated in patients with diabetes. Diabetologia. 2005; 48(5): 1017-21. doi: 10.1007/s00125-005- 1715-5. PMID: 15778859.
Lowe G. Common risk factors for both arterial and venous thrombosis. Br J Haematol. 2008; 140(5): 488- 95. doi: 10.1111/j.1365-2141.2007.06973.x. PMID: 18275426.
Movahed MR, Hashemzadeh M, Jamal MM. The prevalence of pulmonary embolism and pulmonary
hypertension in patients with type II diabetes mellitus. Chest. 2005; 128(5): 3568-71. doi: 10.1016/S0012- 3692(15)52932-2.
Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Cardiovascular risk factors and venous
thromboembolism. Circulation. 2008; 117(1): 93-102. doi: 10.1161/CIRCULATIONAHA.107.709204.
PMID: 18086925.
Holst AG, Prescott E. Risk Factors for Venous Thromboembolism: Results From the Copenhagen City
Heart Study. Circulation. 2009; 120(Suppl 18): S535-S.
Liu A, Huang J, Huang J. Generalized venous thrombosis in diabetic ketoacidosis: A case report and
review. Open J Clin Med Case Rep. 2017: 1207.
Anderson FA, Spencer FA. Risk factors for venous thromboembolism. Circulation. 2003; 107(23 suppl 1):
I-9. doi: 10.1161/01.CIR.0000078469.07362.E6.
Anand SS, Wells PS, Hunt D, Brill-Edwards P, Cook D, Ginsberg JS. Does this patient have deep vein
thrombosis? JAMA. 1998; 279(14): 1094-9. doi: 10.1001/jama.279.14.1094. PMID: 9546569.
Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuünemann HJ. Executive summary: Antithrombotic
Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based
Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl): 7S-47S. doi: 10.1378/chest.1412S3. PMID:
, PMCID: PMC3278060.
Piazza G, Goldhaber SZ, Kroll A, Goldberg RJ, Emery C, Spencer FA. Venous thromboembolism in
patients with diabetes mellitus. Am J Med. 2012; 125(7): 709-16. doi: 10.1016/j.amjmed.2011.12.004.
PMID: 22560173, PMCID: PMC3424058.
Lu DY, Huang CC, Huang PH, Chung CM, Lin SJ, Chen JW, et al. Metformin use in patients with type 2
diabetes mellitus is associated with reduced risk of deep vein thrombosis: a non-randomized, pair-matched
cohort study. BMC cardiovascular disorders. 2014; 14(1): 187. doi: 10.1186/1471-2261-14-187. PMID:
, PMCID: PMC4274716.
Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Frequency, risk factors, and trends for
venous thromboembolism among hospitalized cancer patients. Cancer. 2007; 110(10): 2339-46. doi:
1002/cncr.23062. PMID: 17918266.
Yamada N, Hanzawa K, Ota S, Nakamura M, Sato K, Ikura M, et al. Occurrence of deep vein thrombosis
among hospitalized non-surgical Japanese patients. Annals of vascular diseases. 2015; 8(3): 203-9. doi:
3400/avd.oa.14-00132. PMID: 26421068, PMCID: PMC4575331.
Miri M, Goharani R, Sistanizad M. Deep Vein Thrombosis among Intensive Care Unit Patients; an
Epidemiologic Study. Emergency. 2017; 5(1.. doi: 10.1016/j.amjcard.2003.09.057. PMID: 14715365.
Fekri MS, Zade MK, Fatehi S. The association of deep vein thrombosis with cancer treatment modality:
chemotherapy or surgery? Iranian Red Crescent Medical Journal. 2014; 16(9).
Goldhaber SZ, Tapson VF, Committee DFS. A prospective registry of 5,451 patients with ultrasound- confirmed deep vein thrombosis. Am J Cardiol. 2004; 93(2): 259-62. PMID: 14715365.
Keenan CR, Murin S, White RH. High risk for venous thromboembolism in diabetics with hyperosmolar
state: comparison with other acute medical illnesses. J Thromb Haemost. 2007; 5(6): 1185-90. doi:
1111/j.1538-7836.2007.02553.x. PMID: 17403099.
Sun K, Wang C, Pang B, Yang Y, He W, Chen T, et al. Study on the risk factors of deep venous thrombosis
in acute hospitalized stroke patients. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25(12): 1019-23. PMID:
Low FZ, Yeow RCH, Yap HK, Lim JH, editors. Study on the use of soft ankle-foot exoskeleton for
alternative mechanical prophylaxis of deep vein thrombosis. 2015. IEEE International Conference on
Rehabilitation Robotics. doi: 10.1109/ICORR.2015.7281264.
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