A review of effective herbal medicines in controlling menopausal symptoms
Keywords:
Menopause, Hot flashes, Phytoestrogens, Medicinal plants, Insomnia, Vaginal atrophyAbstract
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause.
Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms.
Methods: This review article was carried out by examining clinical trial studies between the period of 1994 and 2016. The keywords, which include menopause, climacteric, hot flushes, flashes, herb and phytoestrogens were used to search for herbal medicines used in clinical trials for the treatment of menopausal symptoms using databases such as PubMed, Medline, Scopus, Google scholar, SID and Magiran.
Results: The results of the study showed that the medicinal plants, which include Sage herb (Salvia officinalis), Lemon balm (Melissa officinalis), Valerina officinalis, Black cohosh (Cimicifuga racemosa), Fenugreek (Trigonella foenum-graecum), Black cumin (Nigella sativa), Vitex (Vitex agnus-castus), Fennel (Foeniculum vulgare), Evening primrose (Oenothera biennis), Ginkgo biloba, Alfalfa (Medicago sativa), Hypericum perforatum, Panax ginseng, Pimpinella anisum, Licorice (Glycyrrhiza glabra), Passiflora incarnata, Red clover (Trifolium pratense), and Glycine soja were effective in the treatment of acute menopausal syndrome with different mechanisms.
Conclusion: Medicinal plants can play an imperative role in the treatment of acute menopausal syndrome; however, further studies are required to buttress their efficacy in the treatment of acute menopausal syndrome.
References
Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod.
; 1: 81–7. PMID: 3558758.
Brokaw JJ, Tunnicliff G, Raess BU, Saxon DW. The teaching of complementaryand alternative medicine
in U.S. medical schools: a survey of course directors. Acad Med. 2002; 77(9): 876-81. PMID: 12228082.
Ginsburg J. What determines the age at the menopause? BMJ. 1991; 302: 1288–9. doi:
1136/bmj.302.6788.1288. PMID: 2059681, PMCID: PMC1670030.
Prelevic GM, Jacobs HS. Menopause and post-menopause. Baillieres Clin Endocrinol Metab. 1997; 3: 46–
doi: 10.1016/S0950-351X(97)80317-5.
Dennerstein L, Smith AMA, Morse C, Burger H, Green A, Hopper J, et al. Menopausal symptoms in
Australian women. Med J Aus. 1993; 159: 232-6. PMID: 8412889.
Speroff L, Glass K, Kase H. Clinical gynecology and infertility. 7th ed. Philadelphia: Williams &
Wilkings; 2005.
Eisenberg DM, Davis RB, Ettner SL. Trends in alternative medicine use in the United States, 1990-1997.
JAMA. 1998; 280(18): 1569-75. PMID: 9820257.
Ee C, Xue C, Chondros P, Myers SP, French SD, Teede H, et al. Acupuncture for menopausal hot flashes a
randomized trial. Ann Intern Med. 2016; 164(3): 146-54. doi: 10.7326/M15-1380. PMID: 26784863.
MacLennan A, Lester S, Moore V. Oral estrogen replacement therapy versusplacebo for hot flushes: a
systematic review. JAMA. 2001; 4: 58-74. PMID: 11379379.
Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Am J Obstet Gynecol. 1996; 87(5):
-904. PMID: 8677131.
Duncan AM, Phipps WR, Kurzer MS. Phyto-estrogens. Planta Med. 2003; 17(2): 253-71. doi: 10.1055/s- 0030-1250074. PMCID: PMC3800092.
Adlercreutz H, Hamalainen E, Gorbach S, Goldin B. Dietary phyto-estrogens andthe menopause in Japan.
Lancet. 1992; 339: 1233. PMID: 1349965.
Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Dietary effects on breast cancer risk in Singapore.
Lancet. 1991; 337: 1197-1200. doi: 10.1016/0140-6736(91)92867-2. PMID: 1349965.
Xu WH, Zheng W, Xiang YB, Ruan ZH, Cheng GR, Dai QI, et al. Soya food intake and risk of endometrial
cancer among Chinese women in Shanghai: population based case-control study. BMJ. 2004; 328(7451):
doi: 10.1136/bmj.38093.646215.AE. PMID: 15136343, PMCID: PMC420166.
Tsuchida K, Mizushima S, Toba M, Soda K. Dietary soybeans intake and bone mineral density among 995
middle-aged women in Yokohama. Jpn J Clin Oncol. 1999; 9(1): 14-19. PMID: 10098348.
Vandecasteele K, Ost P, Oosterlinck W. Evaluation of the efficacy and safety of Salvia officinalis in
controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytotherapy. 2012;
(2): 208-13. doi: 10.1002/ptr.3528.
Taavoni S, Nazem Ekbatani N, Haghani H. Valerian/lemon balm use for sleep disorders during menopause.
Complement Ther Clin Pract. 2013; 19(4): 193-6. doi: 10.1016/j.ctcp.2013.07.002. PMID: 24199972.
Kazemian A, Banaian SH, Parvin N, Delaram M. The effect of valerian on hot flash in menopausal women.
ijpr. 2006; 8: 35–40.
Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res.
; 12: 217–22. PMID: 24250592, PMCID: PMC3813196.
Bradley P. British Herbal Compendium. Bournemouth, Dorset, England: British Herbal Medicine
Association; 2000: 35-44.
Duker EM, Kopanski L, Jarry H, Wuttke W. Effects of extracts from Cimicifugaracemosaon gonadotropin
release in menopausal women. Planta Med. 1991; 57(5): 420-4. doi: 10.1055/s-2006-960139. PMID:
, PMCID: PMC3813196.
Hakimi S, Mohammd A, Charadabi S, Siahi M, Bamdad R, Abbasalizadeh F, et al. Effect of Fenugreek
seed on early menopausal symptoms. Pharm Sci. 2005; 2: 9.
Ghazanfarpour M, Sadeghi R, Abdolahian S, Latifnejad R. The efficacy of Iranian herbal medicines in
alleviating hot flashes: A systematic review. Int J Reprod. 2016; 14(3): 155-66.
Ibrahim RM, Hamdan NS, Ismail M, Saini SM, Abd Rashid SN, Abd Latiff L, et al. Protective Effects of
Nigella sativa on Metabolic Syndrome in Menopausal Women. 2014; 4(1): 29-33. doi:
5681/apb.2014.005.
Abbaspoor Z, Hajikhani NA, Afshari P. Effect of vitexagnuscactus on menopausal early symptoms in
postmenopausal women: A randomized, double-blind, placebo-controlled study. Br J Med Res. 2011; 1:
–40. doi: 10.9734/BJMMR/2011/163.
Yaralizadeh M, Abedi P, Najar S, Namjoyan F, Saki A. Effect of Foeniculumvulgare (fennel) vaginal
cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial.
Maturitas. 2016; 84: 75-80. doi: 10.1016/j.maturitas. PMID: 26617271.
Chenoy R, Hussain S, Tayob Y, O'Brien PM, Moss MY, Morse PF. Effect of oral gamolenic acid from
evening primrose oil on menopausal flushing. BMJ. 1994; 308: 501–3. doi: 10.1136/bmj.308.6927.501.
PMID: 8136666, PMCID: PMC2542782.
Elsabagh S, Hartley DE, File SE. Limited cognitive benefits in Stage +2 postmenopausal women after 6
weeks of treatment with Ginkgo biloba. J Psychopharmacol. 2005; 19(2): 173-81. doi:
1177/0269881105049038. PMID: 15728439.
DeLeo V, Lanzetta D, Cazzavacca R, MorganteG. Treatment of neurovegetative menopausal symptoms
with a phytotherapeutic agent. Minerva Ginecol. 1998; 50(5): 207-11. PMID: 9677811.
AbdaliKh, Khajehei M, Tabatabaee H. Effects of Hypericum perforatum (St. John's wort) on hot flashes
and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2010; 17(2): 326-3.
Lindgren R, Mattsson LA, Meier W, Wiklund I. Has Ginsana any estrogen effects when measured by
maturity index, plasma FSH, and estradiol? Menopause. 1997; 4: 248. doi: 10.1097/00042192-199704040- 00046.
Nahidi F, Kariman N, Simbar M, Mojab F. The study on the effects of Pimpinellaanisum on relief and
recurrence of menopausal hot flashes. Iran J Pharm Res. 2012; 11: 1079. PMID: 24250540, PMCID:
PMC3813162.
Asgari P, Bahramnezhad F, Narenji F, Golitaleb M, Askari M. A clinical study of the effect of
Glycyrrhizaglabra plant and exercise on the quality of life of menopausal women. Prev Chronic Dis. 2015;
(2): 79-86.
Lakhan SE, Vieira KF. Nutritional and herbal supplements for anxiety and anxiety-related disorders:
systematic review. Nutr J. 2010; 9: 42. doi: 10.1186/1475-2891-9-42. PMID: 20929532, PMCID:
PMC2959081.
Ehsanpour S, Salehi K, Zolfaghari B, BakhtiariS. The effects of red clover on quality of life in post- menopausal women. Iran J Nurs Midwif Res. 2012; 17: 34–40. PMID: 23493172, PMCID: PMC3590693.
Hanachi P, Golkho S. Assessment of soy phytoestrogens and exercise on lipid profiles and menopause
symptoms in menopausal women. J Biol Sci. 2008; 8: 789–93. doi: 10.3923/jbs.
Emami A, Fasihi SH, Mehregan I. PDR for Herbal Medicines, 4th ed. Tehran: Institute for the History of
Islamic and Complementary Medicine; 1389.
Hsieh MT, Wu CR, Wang WH, Lin LW. The ameliorating effect of the water layer of Fructus Schisandrae
on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.
Pharmacol Res. 2001; 43(1): 17-22. doi: 10.1006/phrs.2000.0756. PMID: 11207061.
Orth-Wagner S, Ressin Wj, Friedrich I. Phyto sedativum gegen Schlafstorungen. Z Phytother. 1995; 16(3):
-56.
Santon MS, Ferreira F, Cunha AP, Carvalho AP, Macedo T. An aqueous extract of Valerian influences the
transport of Gaba in synaptosomes. Planta Med. 1994; 60: 278-9. doi: 10.1055/s-2006-959476. PMID:
Medraś M, Milewicz A, Ziotas G. Evaluation of estradiol response to antiestrogen stimulation in fertile and
oligozoospermic men reacting both positively and negatively to chronic treatment with clostilbegyt.
Endokrynol Pol. 1993; 44(4): 477-82. PMID: 8055816.
Milewicz A, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, et al. Vitex agnus castus extract
in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo- controlled double-blind study. Arzneimittelforschung. 1993; 43(7): 752-6. PMID: 8369008.
Javidnia K, Dastgheib L, Mohammadi Samani S, Nasiri A. Antihirsutism activity of Fennel (fruits of
Foeniculum vulgare) extract. A double-blind placebo controlled study. Phytomedicine. 2003; 10(6-7): 455- 8. doi: 10.1078/094471103322331386. PMID: 13678227.
Lancel M, Faulhaber J, Holsboer F, Rupprecht R. Progesterone induces changes in sleep comparable to
those of agonistic GABAA receptor modulators. Am J Physiol. 1996; 271(4 Pt 1): E763-72. PMID:
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