Fatigue and Depression in Iranian Amyotrophic Lateral Sclerosis Patients in Tehran in 2012

Authors

  • Azizreza Ghasemzadeh Lecturer in Rehabilitation Science, University of Applied Sciences, Tehran Welfare Organization, Tehran, Iran

Keywords:

Amyotrophic Lateral Sclerosis, Fatigue, Depression, Iran

Abstract

Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a progressive and rapid course. Fatigue and depression are common among ALS patients. The aim of this study was to determine the relationship between depression and fatigue in Iranian ALS patients.

Methods: In this 2012 cross-sectional study, 40 ALS patients, including 22 females and 18 males, were selected through consecutive relapsing-remitting, and 40 age- and gender-matched health controls (HCs) were recruited from Loghman Hakim Hospital in Tehran, Iran. The Persian version of the Fatigue Severity Scale (FSS-Per) questionnaire and depression substance of Hospital Anxiety and Depression Scale (HADS) were used to assess fatigue and depression. Data were analyzed using the Kolmogorov-Sminov Test, Levene's test, Independent Samples t-test, and Pearson product-moment correlation coefficient.

Results: We identified a significant and positive relationship between fatigue and depression in patients with ALS (p=0.000). Furthermore, the scores of fatigue and depression in ALS patients were higher than in non-ALS patients. 

Conclusion: The results indicated that there was a relationship between fatigue and depression in ALS patients and that early intervention services can improve these symptoms. Further studies are suggested to investigate the direction of such relationship.

 

References

Ng L, Kh F. Multidisciplinary Rehabilitation in Amyotrophic Lateral Sclerosis. Amyotrophic Lateral

Sclerosis. InTech. 2012. doi: 10.5772/31774.

Stromberg, Shannon F, Weiss DB. Depression And Quality Of Life Issues In Patients With Amyotrophic

Lateral Sclerosis. Curr Treat Options Neurol. 2006; 8(5): 410-4. Web. doi: 10.1007/s11940-006-0030-x.

PMID: 16901380.

Vucic S, Cheah B, Kiernan M. Maladaptation of cortical circuits underlies fatigue and weakness in ALS.

Amyotroph Lateral Scler. 2011; 12(6): 414-20. doi: 10.3109/17482968.2011.597403. PMID: 21830989.

Lulé D, Häcker S, Ludolph A, Birbaumer N, Kübler A. Depression and Quality of Life in Patients With

Amyotrophic Lateral Sclerosis. Dtsch Arztebl Int. 2008; 105(23): 397–403. doi:

3238/arztebl.2008.0397. PMID: 19626161, PMCID: PMC2696844.

Diaz J, Sancho J, Barreto P, Banuls P, Renovell M, Servera E. Effect of a short-term psychological

intervention on the anxiety and depression of amyotrophic lateral sclerosis patients. J Health Psychol. 2014.

doi: 10.1177/1359105314554819. PMID: 25370571.

Atassi N, Cook A, Pineda C, Yerramilli-Rao P, Pulley D, Cudkowicz M. Depression in amyotrophic lateral

sclerosis. Amyotroph Lateral Scler. 2011; 12(2): 109-12. doi: 10.3109/17482968.2010.536839. PMID:

, PMCID: PMC3155886.

Pagnini F. Psychological wellbeing and quality of life in amyotrophic lateral sclerosis: A review. Int J

Psychol. 2013; 48(3): 194-205. doi: 10.1080/00207594.2012.691977. PMID: 22731673.

Epton J, Harris R, Jenkinson C. Quality of life in amyotrophic lateral sclerosis/motor neuron disease: A

structured review. Amyotroph Lateral Scler. 2009; 10(1): 15-26. doi: 10.1080/17482960802163721. PMID:

Lou J, Reeves A, Benice T, Sexton G. Fatigue and depression are associated with poor quality of life in

ALS. Neurology. 2003; 60(1): 122-3. doi: 10.1212/01.wnl.0000042781.22278.0a. PMID: 12525733.

Montazeri A, Torkan B, Omidvari S. The Edinburgh Postnatal Depression Scale (EPDS): translation and

validation study of the Iranian version. BMC Psychiatry. 2007; 7(1): 11. doi: 10.1186/1471-244x-7-11.

PMID: 12816545.

Seyedian M, Falah M, Nourouzian M, Nejat S, Delavar A, Ghasemzadeh HA. Validity of the Farsi Mini- Mental State Examination. JMCIRI. 2008; 25(4): 408-14.

Azimian M, Shahvarughi Farahani A, Dadkhah A, Fallahpour M, Karimlu M. Fatigue Severity Scale: The

Psychometric Properties of the Persian-Version in Patients with Multiple Sclerosis. RJBS. 2009; 4(9): 974- 7.

Jenkins T, Hollinger H, McDermott C. The evidence for symptomatic treatments in amyotrophic lateral

sclerosis. Curr Opin Neurol. 2014; 27(5): 524-31. doi: 10.1097/wco.0000000000000135. PMID: 25110934.

McElhiney M, Rabkin J, Gordon P, Goetz R, Mitsumoto H. Prevalence of fatigue and depression in ALS

patients and change over time. J Neurol Neurosurg Psychiatry. 2009; 80(10): 1146-9. doi:

1136/jnnp.2008.163246. PMID: 19762902.

Matza L, Murray L, Phillips G, Konechnik T, Dennehy E, Bush E, et al. Qualitative Research on Fatigue

Associated with Depression: Content Validity of the Fatigue Associated with Depression Questionnaire

(FAsD-V2). Patient. 2015; 8(5): 433-43. doi: 10.1007/s40271-014-0107-7. PMID: 25613915, PMCID:

PMC4575372.

Published

2022-03-07

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