The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes
A randomized double-blinded controlled trial
Keywords:
Vitamin D, Type 2 diabetes, Adiponectin, Insulin resistance, First degree relativesAbstract
Background: Despite the certain role of both vitamin D and adiponectin in the regulation of insulin sensitivity, the interaction between these two agents has remained uncertain.
Objective: The present study aimed to determine whether vitamin D is able to change plasma adiponectin and affect glucose homeostasis and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes.
Methods: This randomized clinical trial was conducted at Clinic of Shahid Sadoughi Hospital in Yazd, Iran, from January 25, 2012 to December 25, 2014. In this randomized, double-blinded controlled trial, 64 first-degree relatives of type 2 diabetic patients were assigned randomly to receive either vitamin D supplement (50000 IU vitamin D tablet weekly) plus lifestyle change as the intervention group (n = 32) or placebo plus lifestyle change as the control group (n = 32) for twelve weeks (three months).
Results: Fifty-three patients (28 in the intervention group and 25 in the control group) completed the study. Serum levels of vitamin D increased while insulin level and consequently insulin resistance (calculated by HOMA formula) significantly decreased in the case group (p-value <0.001 for all variables). Although the values of these three biomarkers showed a slight increase in control group, the changes were not statistically significant. The levels of the changes in other markers including adiponectin, Fasting Blood Sugar (FBS), triglyceride, and total cholesterol remained insignificant in both study groups after completing interventions compared with before interventions.
Conclusion: This study showed that decreased insulin resistance is expected by administrating vitamin D supplement in first-degree relatives of the patients with diabetes mellitus.
Trial Registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT ID: 201105176430N1.
Funding: The authors received no financial support for the research or publication of this article.
References
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011; 34:
Suppl 1: S62-9. doi: 10.2337/dc11-S062.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care. 2004; 27:
- 53. doi: 10.2337/diacare.27.5.1047, PMID: 15111519.
Afkhami-Ardekani M, Vahidi S, Vahidi A, Ahmadieh MH. Assessment of Epidemiological Indices of
Diabetes Mellitus in Urban Population Of Yazd province aged ≥30 in 1998. Journal of Yazd Shahid
Sadoughi University of Medical Sciences. 2001; 1: 22-7.
Zeitz U, Weber k, Soegiarto DW, Wolf E, Balling R, Erben RG. Impaired insulin secretory capacity in
mice looking a functional vitamin D receptor. FASEB J. 2003; 17(3): 509-11. PMID: 12551842.
Ford E, Ajani UA, McGuire LC, Liu S. Concentration of serum vitamin D and the metabolic syndrome
Among U.S Adult. Diabetes care. 2005; 28(5): 1228-30. doi: 10.2337/diacare.28.5.1228, PMID: 15855599.
Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB. Circulating adiponectin levels are associated with
better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2
diabetes. J Clin Endocrinol Metab. 2005; 90(8): 4542-8. doi: 10.1210/jc.2005-0372, PMID: 15914524.
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and Adiponectin receptors in
insulin resistance, diabetes, and metabolic syndrome. J Clin Invest. 2006; 116(7): 1784-92. doi:
1172/JCI29126, PMID: 16823476, PMCID: PMC1483172.
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat derived hormone adiponectin
reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001; 7(8): 941-6. doi:
1038/90984, PMID: 11479627.
Li s, Shin JJ, Ding El, Van Dam RM. Adiponectin levels and risk of Type 2 diabetes: A systematic review
and meta-analysis. JAMA. 2009; 302(2): 179-88. doi: 100.1001/jama.2009.976, PMID: 19584347.
Soheilykhah S, Mohammadi M, Mojibian M, Rahimi-Saghand S, Rashidi M, Hadinedoushan,H, et al.
Maternal serum adiponectin concentration in gestational diabetes. Gynecol Endocrinol. 2009; 25(9): 593-6.
doi: 10.1080/09513590902972109, PMID: 19626510.
Von Hurst PR, stonehouse W, Matthys C, conlon C, Kruger MC, Coad J. Study protocol-Metabolic
syndrome, vitamin D and bone status. In south Asian women living in Auckland, New Zealand: a
randomized placebo-controlled, double-blind vitamin D intervention. BMC Public health. 2008; 8: 267-74.
doi: 10.1186/1471-2458-8-267, PMID: 18667086.
Petchey WG, Hickman IJ, Duncan E, Prins JB, Hawley CM, Johnson DW, et al. The role of 25-Hydrody
vitamin D deficiency in promoting insulin resistance and inflammation in patients with cronic kidney
disease: a randomized controlled trial. BMC nephrology. 2009; 10: 41-6. doi: 10.1186/1471-2369-10-41,
PMID: 20003316.
Talaei A, Mohamadi M, Adgi Z. The effect of vitamin D on insulin resistance in patients with type 2
diabetes. Diabetol Metab Syndr. 2013; 5(8): 1-5. doi: 10.1186/1758-5996-5-8, PMID: 23443033.
Pittas AG, Harris SS, Stark pc. Dawson Hoghes B. the effect of calcium and vitamin D supplement on
Blood Glucose Marker of inflammation in nondiabetic Adult. Diabetes care. 2007; 30(4): 980-6. PMID:
Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term
effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally
obese men. Diabetic Medicine. 2009; 26(1): 19-27. doi: 10.1111/j.1464-5491.2008.02636.x, PMID:
Gannage-Yared MH, chedid R, khalifes, sohbif, Halady G. vitamin D in relation to metabolic risk factor,
insulin sensitivity and adiponectin in a young middle- Eastern population. Eur J Endocrinol. 2009; 160(6):
-71. doi: 10.1530/EJE-08-0952, PMID: 19289535.
Liu E, Meigs JB, Pittas AG, McKeown NM, Economos CD, Booth SL, et al. Plasma 25-Hydroxy vitamin
D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. 2009; 139(2):
-34. doi: 10.3945/jn.108.093831, PMID: 19106328.
Afkhami-Ardekani M, Shojaoddiny-Ardekani A. Effect of vitamin C on blood glucose, serum lipids &
serum insulin in type 2 diabetes patients. Indian J Med Res. 2007; 126(5): 471-4. PMID: 18160753.
Published
Issue
Section
License
Copyright (c) 2020 KNOWLEDGE KINGDOM PUBLISHING
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
