A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua
Keywords:
Artemisia annua, Phytochemicals, Therapeutic effects, Pharmacognosy, Alternative and complementary medicineAbstract
Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and anti-cancer properties. This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified approximately ninety eight references. In this study, forty six studies were accepted for further screening and met all of our inclusion. The search terms were “Artemisia annua”, “therapeutic properties”, “and pharmacological effects”. Artemisia annua is commonly used for its anti-malarial, immunosuppressive anti-inflammatory properties. Artemisia annua contributes to the treatment of various diseases such as diabetes, heart diseases, arthritis and eczema and possesses various effects such as antibacterial, antioxidant, anticoccidial, and antiviral effects. Furthermore, it was said to be good for cancer treatment. In this study, anti-malarial, immunosuppressive, anti-inflammatory properties of this plant are presented using published articles in scientific sites.
References
Masoudi M, Miraj S, Rafieian-Kopaei M. Comparison of the Effects of Myrtus Communis L, Berberis
Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis. J Clin Diagn Res.
; 10(3): QC04-7. doi: 10.7860/JCDR/2016/17211.7392. PMID: 27134945, PMCID: PMC4843330.
Baghbahadorani FK, Miraj S. The impact of Silymarin on improvement of platelet abnormalities in patients
with severe preeclampsia. Electron Physician. 2016; 8(5): 2436-42. doi: 10.19082/2436. PMID: 27382456,
PMCID: PMC4930266.
Eftekhar M, Miraj S, Mortazavifar Z. The effect of luteal phase gonadotropin-releasing hormone antagonist
administration on IVF outcomes in women at risk of OHSS. Int J Reprod Biomed (Yazd). 2016; 14(8):
-10. PMID: 27679825, PMCID: PMC5015664.
Miraj S, Kiani S. Study of pharmacological effect of Avena sativa: A review. Der Pharmacia Lettre. 2016;
(9): 137-40.
Miraj S, Kiani S. Study of pharmacological effect of Mentha pulegium: A review. Der Pharmacia Lettre. 2016; 8(9): 242-5.
Miraj S, Kiani S. Study of pharmacological effect of Ocimum basilicum: A review. Der Pharmacia Lettre.
; 8(9): 276-80.
Miraj S, Kiani S. Study of therapeutic effects of Cynara scolymus L. A review. Der Pharmacia Lettre.
; 8(9): 168-73.
Miraj S, Azizi N, Kiani S. A review of chemical components and pharmacological effects of Melissa
officinalis L. Der Pharmacia Lettre. 2016; 8(6): 229-37.
Miraj S, Kiani S. Bioactivity of Sesamum indicum: A review study. Der Pharmacia Lettre. 2016; 8(6): 328- 34.
Miraj S, Kiani S. A review study of therapeutic effects of Salvia officinalis L. Der Pharmacia Lettre. 2016;
(6): 299-303.
Hwang DI, Won KJ, Kim DY, Yoon SW, Park JH, Kim B, et al. Anti-adipocyte Differentiation Activity
and Chemical Composition of Essential Oil from Artemisia annua. nat prod commun. 2016; 11(4): 539-42.
PMID: 27396213.
Desrosiers MR, Weathers PJ. Effect of leaf digestion and artemisinin solubility for use in oral consumption
of dried Artemisia annua leaves to treat malaria. J ethnopharmacol. 2016; 190: 313-8. doi:
1016/j.jep.2016.06.041. PMID: 27340104, PMCID: PMC5010509.
Ruan JX, Li JX, Fang X, Wang LJ, Hu WL, Chen XY, et al. Isolation and Characterization of Three New
Monoterpene Synthases from Artemisia annua. Front Plant Sci. 2016; 7: 638. doi:
3389/fpls.2016.00638. PMID: 27242840, PMCID: PMC4861830.
Bryant L, Patole C, Cramer R. Proteomic analysis of the medicinal plant Artemisia annua: Data from leaf
and trichome extracts. Data Brief. 2016; 7: 325-31. doi: 10.1016/j.dib.2016.02.038. PMID: 26977431,
PMCID: PMC4781977.
Kim KE, Ko KH, Heo RW, Yi CO, Shin HJ, Kim JY, et al. Artemisia annua Leaf Extract Attenuates
Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice. J med food. 2016; 19(3): 290-9. doi:
1089/jmf.2015.3527. PMID: 26741655, PMCID: PMC4799707.
Derda M, Hadas E, Cholewinski M, Skrzypczak L, Grzondziel A, Wojtkowiak-Giera A. Artemisia annua
L. as a plant with potential use in the treatment of acanthamoebiasis. Parasitol res. 2016; 115(4): 1635-9.
doi: 10.1007/s00436-016-4902-z. PMID: 26782959, PMCID: PMC4799240.
Michaelsen FW, Saeed ME, Schwarzkopf J, Efferth T. Activity of Artemisia annua and artemisinin
derivatives, in prostate carcinoma. Phytomedicine. 2015; 22(14): 1223-31. doi:
1016/j.phymed.2015.11.001. PMID: 26655404.
Ko YS, Lee WS, Panchanathan R, Joo YN, Choi YH, Kim GS, et al. Polyphenols from Artemisia annua L
Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231. Phytother Res. 2016;
(7): 1180-8. doi: 10.1002/ptr.5626. PMID: 27151203.
Dilshad E, Zafar S, Ismail H, Waheed MT, Cusido RM, Palazon J, et al. Effect of Rol Genes on
Polyphenols Biosynthesis in Artemisia annua and Their Effect on Antioxidant and Cytotoxic Potential of
the Plant. App biochem biotechnol. 2016; 179(8): 1456-68. doi: 10.1007/s12010-016-2077-9. PMID:
Xiong S, Tian N, Long J, Chen Y, Qin Y, Feng J, et al. Molecular cloning and characterization of a
flavanone 3-Hydroxylase gene from Artemisia annua L. Plant Physiol Biochem. 2016; 105: 29-36. doi:
1016/j.plaphy.2016.04.005. PMID: 27070290.
Youyou T, Muyun N, Yurong Z, Lanna L, Shulian G, Muqun Z, et al. studies on the constituents of
artemisia annua l. Yao Xue Xue Bao. 2015; 50(10): 366-70. PMID: 26837162.
Kiani BH, Suberu J, Mirza B. Cellular engineering of Artemisia annua and Artemisia dubia with the rol
ABC genes for enhanced production of potent anti-malarial drug artemisinin. Malar J. 2016; 15(1): 252.
doi: 10.1186/s12936-016-1312-8. PMID: 27142388, PMCID: PMC4855502.
Pulice G, Pelaz S, Matias-Hernandez L. Molecular Farming in Artemisia annua, a Promising Approach to
Improve Anti-malarial Drug Production. Front Plant Sci. 2016; 7: 329. doi: 10.3389/fpls.2016.00329.
PMID: 27047510, PMCID: PMC4796020.
Engeu PO, Omujal F, Agwaya M, Kyakulaga H, Obua C. Variations in antimalarial components of
Artemisia annua Linn from three regions of Uganda. Afr Health Sci. 2015; 15(3): 828-34. doi:
4314/has.v15i3.17. PMID: 26957971, PMCID: PMC4765468.
Khan S, Ali A, Ahmad S, Abdin MZ. Affordable and rapid HPTLC method for the simultaneous analysis
of artemisinin and its metabolite artemisinic acid in Artemisia annua L. Biomed Chromatogr. 2015; 29(10):
-603. doi: 10.1002/bmc.3465. PMID: 25829259.
Kiani BH, Suberu J, Mirza B. Cellular engineering of Artemisia annua and Artemisia dubia with the rol
ABC genes for enhanced production of potent anti-malarial drug artemisinin. Malar J. 2016; 15(1): 252.
doi: 10.1186/s12936-016-1312-8. PMID: 27142388, PMCID: PMC4855502.
Jiang W, Fu X, Tang Y, Shen Q, Lv Z, Yan T, et al. Overexpression of AaWRKY1 Leads to an Enhanced
Content of Artemisinin in Artemisia annua. BioMed Res Int. 2016; 1: 9. doi: 10.1155/2016/7314971.
Pulice G, Pelaz S, Matías-Hernández L. Molecular Farming in Artemisia annua, a Promising Approach to
Improve Anti-malarial Drug Production. Front Plant Sci. 2016; 7: 329. doi: 10.3389/fpls.2016.00329.
PMID: 27047510, PMCID: PMC4796020.
Engeu PO, Omujall F, Agwaya M, Kyakulaga H, Obua C. Variations in antimalarial components of
Artemisia annua Linn from three regions of Uganda. Afr Health Sci. 2015; 15(3): 828-34. doi:
4314/ahs.v15i3.17. PMID: 26957971, PMCID: PMC4765468.
Weathers PJ, Towler M, Hassanali A, Lutgen P, Engeu PO. Dried-leaf Artemisia annua: A practical
malaria therapeutic for developing countries? World J Pharmacol. 2014; 3(4): 39-55. doi:
5497/wjp.v3.i4.39. PMID: 25678989, PMCID: PMC4323188.
Elfawal MA, Towler MJ, Reich NG, Weathers PJ, Rich SM. Dried whole-plant Artemisia annua slows
evolution of malaria drug resistance and overcomes resistance to artemisinin. Proc Natl Acad Sci U S A.
; 112(3): 821-6. doi: 10.1073/pnas.1413127112. PMID: 25561559, PMCID: PMC4311864.
Zhang YX, Sun HX. Immunosuppressive effect of ethanol extract of Artemisia annua on specific antibody
and cellular responses of mice against ovalbumin. Immunopharmacol Immunotoxicol. 2009; 31(4): 625-30.
doi: 10.3109/08923970902932954. PMID: 19874232.
Noori S, Naderi GA, Hassan ZM, Habibi Z, Bathaie SZ, Hashemi SM. Immunosuppressive activity of a
molecule isolated from Artemisia annua on DTH responses compared with cyclosporin A. Int
Immunopharmacol. 2004; 4(10-11): 1301-6. doi: 10.1016/j.intimp.2004.05.003. PMID: 15313428.
Stebbings S, Beattie E, McNamara D, Hunt S. A pilot randomized, placebo-controlled clinical trial to
investigate the efficacy and safety of an extract of Artemisia annua administered over 12 weeks, for
managing pain, stiffness, and functional limitation associated with osteoarthritis of the hip and knee. Clin
rheumatol. 2016; 35(7): 1829-36. doi: 10.1007/s10067-015-3110-z. PMID: 26631103.
Ko YS, Lee WS, Panchanathan R, Joo YN, Choi YH, Kim GS, et al. Polyphenols from Artemisia annua L
Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA‐MB‐231. Phytother Res.
; 30(7): 1180-8. doi: 10.1002/ptr.5626. PMID: 27151203.
Michaelsen FW, Saeed ME, Schwarzkopf J, Efferth T. Activity of Artemisia annua and artemisinin
derivatives, in prostate carcinoma. Phytomedicine. 2015; 22(14): 1223-31. doi:
1016/j.phymed.2015.11.001. PMID: 26655404.
Ahmadi F, Mojarrab M, Ghazi-Khansari M, Hosseinzadeh L. A semipolar fraction of petroleum ether
extract of Artemisia aucheri induces apoptosis and enhances the apoptotic response to doxorubicin in
human neuroblastoma SKNMC cell line. Res Pharm Sci. 2015; 10(4): 335-44. PMID: 26600860, PMCID:
PMC4623622.
Tilaoui M, Mouse HA, Jaafari A, Zyad A. Comparative Phytochemical Analysis of Essential Oils from
Different Biological Parts of Artemisia herba alba and Their Cytotoxic Effect on Cancer Cells. PloS one.
; 10(7): e0131799. doi: 10.1371/journal.pone.0131799.
Kweon SH, Song JH, Kim HJ, Kim TS, Choi BG. Induction of human leukemia cell differentiation via
PKC/MAPK pathways by arsantin, a sesquiterpene lactone from Artemisia santolina. Arch Pharm Res.
; 38(11): 2020-8. doi: 10.1007/s12272-015-0609-4. PMID: 25956697.
Tang C, Zhao Y, Huang S, Jin Y, Liu J, Luo J, et al. Influence of Artemisia annua extract derivatives on
Proliferation, apoptosis and metastasis of osteosarcoma cells. Pak J Pharm Sci. 2015; 28(2Suppl): 773-9.
PMID: 25796153.
Rabe ST, Emami SA, Iranshahi M, Rastin M, Tabasi N, Mahmoudi M. Anti-cancer properties of a
sesquiterpene lactone-bearing fraction from Artemisia khorassanica. Asian Pac J Cancer Prev. 2015; 16(3):
-8. doi: 10.7314/APJCP.2015.16.3.863. PMID: 25735374.
Meiya Li, Fusheng Jiang, Xiangli Yu, Zhiqi Miao. Engineering Isoprenoid Biosynthesis in Artemisia annua
L. for the Production of Taxadiene: A Key Intermediate of Taxol. BioMed res int. 2015; 2015: 8. doi:
1155/2015/504932.
Tayarani-Najaran Z, Hajian Z, Mojarrab M, Emami SA. Cytotoxic and apoptotic effects of extracts of
Artemisia ciniformis Krasch. and Popov ex Poljakov on K562 and HL-60 cell lines. Asian Pac J Cancer
Prev. 2014; 15(17): 7055-9. doi: 10.7314/APJCP.2014.15.17.7055. PMID: 25227790.
Miller LH, Su X. Artemisinin: discovery from the Chinese herbal garden. Cell. 2011; 146(6): 855-8. doi:
1016/j.cell.2011.08.024. PMID: 21907397, PMCID: PMC3414217.
Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L. Randomized controlled trial of a
traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc
Trop Med Hyg. 2004; 98(5): 318-21. doi: 10.1016/j.cell.2011.08.024. PMID: 15109558.
Fairhurst RM, Nayyar GM, Breman JG, Hallett R, Vennerstrom JL, Duong S, et al. Artemisinin-resistant
malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg. 2012;
(2): 231-41. doi: 10.4269/ajtmh.2012.12-0025. PMID: 22855752, PMCID: PMC3414557. 47) Chrubasik C, Jacobson RL. The development of artemisinin resistance in malaria: reasons and solutions.
Phytother Res. 2010; 24(7): 1104-6. doi: 10.1002/ptr.3133. PMID: 20578122.
Miraj S, Kiani S. Astragalus membranaceus: A review study of its anti-carcinoma activities. Der Pharmacia
Lettre. 2016, 8(6): 59-65.
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