Prevalence of hypocalcemia after phototherapy among neonates who underwent phototherapy in Koodakan Hospital in Bandar Abbas in 2013

Authors

  • Elham Homayrani M.D., General Physician, Clinical Research Development Center of Koodakan Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Keywords:

hypocalcemia, phototherapy, hyperbilirubinemia, newborns

Abstract

Introduction: Hyperbilirubinemia is one of the most common problems in newborns, and it is reported in about 60% of infants. Phototherapy is used extensively to treat these patients, and hypocalcemia is one important side effect of the phototherapy. The aim of this study was to determine the prevalence of hypocalcemia after phototherapy in full-term newborns that underwent phototherapy in Koodakan Hospital in Bandar Abbas in 2013.

Methods: This cross-sectional study was conducted on 100 neonates admitted to Koodakan Hospital in Bandar Abbas. All of the newborns were full-term, healthy, weighed more than 2,500 g, and were candidates for phototherapy. The newborns were divided into two groups, i.e., 1) those who were more than three days old and 2) those who were less than three days old. Serum bilirubin and calcium levels were measured for each newborn before phototherapy and 48 hours after phototherapy, and the before and after levels were compared. The data were analyzed using IBM SPSS 21.0 statistical software. The Fisher Exact test, the independent samples t-test, and the paired t-test were used to test the research hypothesis.

Results: Among the 100 newborns studied, 54% had decreased calcium levels after phototherapy. The prevalence of hypocalcemia was 9% in this study, and the prevalence was not significantly different in the two age groups (P = 0.217). 

Conclusion: Phototherapy does not increase the risk of hypocalcemia in healthy, full-term neonates. Therefore, prophylactic calcium is not recommended for healthy, full-term neonates who have undergone phototherapy.

References

kumar Yadav R, Sethi R.S, Sethi A.S, Kumar L, Shankar Chauraisa O. The evaluation of effect of

phototherapy on serum calcium level. PJSR. 2012; 5 (2):1-4.

Kliegman R, Stanton B, Behrman R, Geme J, Schor N. Nelson text book of pediatric.19th ed. 2012.

Jeffrey Maisels A, McDonagh A.F. Phototherapy for neonatal jaundice. NEJM. 2008; 358: 920-8. doi:

1056/NEJMct0708376.

karamifar H, pishva N, Amirhakimi GH. Prevalence of phototherapy induced hypocalcemia. Iran J Med

Sci. 2002; 27 (4):166-8.

A joint statement with the College of Family Physicians of Canada. Approach to the management of

hyperbilirubinemia in term newborn infants. Paediatr Child Health. 1999; 4 (2): 161–70. PMID: 20212978,

PMCID: PMC2828212.

Tatli M, Minnet C, Kocyigit A, Karadag A, Ahmet Karadag. Phototherapy increase DNA damage in

lymphocytes of hyperbilirubinemic neonates. Mutat Res-Gen Tox En. 2008; 654 (1): 93-5. doi:

1016/j.mrgentox.2007.06.013.

Stokowski L.A .Fudamentals of phototherapy for neonatal jaundice. Adv neonatal car. 2011; 11 (5):10-21.

doi: 10.1097/ANC.0b013e31822ee62c.

Habibzadeh F, Karamizadeh Z. Phototherapy-induced hypocalcemia. IJMS. 2002; 27 (4):151.

Eghbalian F. The Study of Early Neonatal Hypocalcemia in the Educational Hospitals of Hamadan

University of Medical Sciences. Scientific Journal of Hamadan University of Medical Sciences and Health

Services. 2004; 11 (3): 48 To 52.

Borkenhagen JF, connor EL, Stafstrom CE. Neonatal hypocalcemic seizure due to excessive maternal

calcium ingestion. Pediatr Neurol. 2013; 48 (6): 469-71. doi: 10.1016/j.pediatrneurol.2013.02.010. PMID:

Korkmaz H.A, Ozkan B, Terek D, Dizdarer C, Arslanoğlu S. Neonatal seizure as a manifestation of

unrecognized maternal hyperparathyroidism. J Clin Res Pediatr Endocrinol. 2013; 5 (3): 206-8.

doi:10.4274/Jcrpe.1037. PMID: 24072092, PMCID: PMC3814538.

Alizadeh-Taheri P, sajjadian N, Eivazzadeh B. Prevalence of phototherapy induced hypocalcemia in term

neonate. Iran J pediatr. 2013; 23 (6): 710-11.

Ehsanipoor F, Khosravi N, Jalali S. The effect of Hat on phototherapy induced hypocalcemia in icteric

newborn. The Razi J Med Sci. 2008; 15 (58): 25-9.

Eghbalian F, monsef A. phototherapy induce hypocalcemia in icteric newborn. Iran J Med Sci. 2002; 27

(4): 169-71.

Hooman N, Honarpisheh A. The effect of phototherapy on urinary calcium excretion in newborn. Pediater

Nephrol. 2005; 20 (9): 1363-4.

jain A, Agarwal R. Shankar M.J, Deorari A, Paul V.K. Hypocalcemia in the newborn. Indin J Pediater.

; 77 (10): 1123-8. doi: 10.1007/s12098-010-0176-0. PMID: 20737250

Published

2022-03-08