Purslane Effect on GLP-1 and GLP-1 receptor in type 2 diabetes
Keywords:
Purslane; Anti-diabetic factors; Type II diabetic womenAbstract
Background: The aim of this study was to examine the effect of purslane seeds in glucagon-like peptide-1 concentration and glucagon-like peptide-1 receptor in women with diabetes.
Methods: This was a quasi-experimental study. The population was consisted of the city of Sari where diabetic women with diabetes II who had no history of using purslane seeds. All individuals used the same dose of metformin under the specialist supervision. Among these individuals, 16 were assigned at random to Purslane group and control group. The purslane group consumed 2.5 grams Purslane with lunch and along with 5 grams of purslane (Portulaca oleracea seeds 7.5 g daily) with dinner meals twice daily for 8 weeks. Blood sample was taken before and after 8 weeks, after 12 hours of fasting to 5 ml of the left brachial vein.
Results: After 8 weeks using purslane seeds in the experimental group, a significant increase was seen in glucagon-like peptide-1 concentrations (p<0.007), but there was no significant difference in the concentration of glucagon-like peptide-1 receptor (p <0.455). No significant relationship was found between changes in glucagon-like peptide-1 and its receptor.
Conclusion: The use of purslane seeds improved Type II diabetes; therefore it can be effective in improving the health of women with diabetes.
References
Abdalla Hussein M, Purslane Extract Effects on Obesity-Induced Diabetic Rats Fed a High-Fat Diet. Mal JNutPr.2010;16(3): 419-29.2.Akhoondzadeh sh. Iranian medicinal plants encyclopedia. Volume1, Tehran, Arjmand Publication.2000:127 43.Chait A, Bierman EL. Pathogenesis of macrovascular disease in diabetes. In: Kahn CR, Weir G (eds).Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 1994: 648-644.King GL, Banskota NK. Mechanisms of diabetic microvascular complication. In: Kahn CR, Weir G(eds).Joslin’s Diabetes Mellitus. Philadelphia. Lea and Febiger. 1994: 631-47
Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia. 2001Feb;44(2): 129-466.Fayong Gong 1, Fenglin Li, Hypoglycemic Effects of Crude Polysaccharide from Purslane. Int. J. Mol. Sci.2009;10:880-8.doi: 10.3390/ijms100308807.Wang W, Gu L, Dong L, Wang X, Ling C, Li M. Protective effect of portulaca oleraceaextracts onhypoxic nerve tissue and its mechanism. Asia Pac J Clin Nutr. 2007; 16(Suppl1):227-338.Burcelin R, Rolland E, Dolci W, Germain S, Carrel V, Thorens B. Encapsulated genetically engineeredcells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus. Ann NY Acad Sci. 1999;875 (June (18)): 277–859.Dharmalingam M, Sriram U, Baruah M.Liraglutide: A review of its therapeutic use as a once daily GLP-1analog for the management of type 2 diabetes mellitus.Indian J Endocrinol Metab. 2011 Jan;15(1):9-17.doi: 10.4103/2230-8210.77571.PubmedPMID:21584160.10.Koole C, Wootten D, Simms J, MillerLJ, Christopoulos A, Sexton PM.Second extracellular loop ofhuman glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptoractivation.J Biol Chem. 2012 Feb 3;287(6):3642-58. doi: 10.1074/jbc.M111.309328.PubmedPMID:2214771011.Radhakrishnan R, Zakaria MN, Islam MW, Chen HB, Kamil M, Chan K, et al. Neuropharmacologicalactions of Portulaca oleraceae L v. sativa (Hawk). J Ethnopharmacol. 2001 Jul; 76(2): 171-612.Rashed AN, Afifi FU, Disi AM. Simple evaluation of the wound healing activity of a crudeextract ofPortulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1. JEthnopharmacol. 2003 Oct; 88(2-3):131-613.Mohamed AI, Hussein AS. Chemical composition of purslane(Portulaca oleracea). Plant FoodsHum Nutr.1994 Jan; 45(1): 1-914.Mizutani M, Hashidoko Y, Tahara S. Factors responsible for inhibiting the motility ofzoospores of thephytopathogenic fungus Aphanomyces cochlioides isolated from the non-hostplant Portulaca oleracea.FEBSLett. 1998 Nov; 438(3): 236-4015.Simopoulos AP, Norman HA, Gillaspy JE, Duke JA. Common purslane: a source of omega-3 fatty acidsand antioxidants. J Am Coll Nutr. 1992 Aug; 11(4): 374-8216.de Lorgeril M, Salen P. Alpha-linolenic acid and coronary heart disease. Nutr MetabCardiovasc Dis. 2004Jun; 14(3): 162-917.Rasheed AN, Afifi FU, Shaedah M, Taha MO. Investigation of the active constituents ofPortulacaoleraceae L. (Portulacaceae) growing in Jordan. Pak J Pharm Sci. 2004 Jan; 17(1):37-4518.Schuman M. Overview of purslane edible and medicinal herb. NNFA Today.2001; 15(6): 1219.El-Sayed MI . Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients asadjunctive and alternative therapy. J Ethnopharmacol. 2011 Sep 1;137(1):643-51. Epub 2011 Jun 2820.Klemens J. Herbs That Lower Blood Sugar. The Online Journal for the American Association ofIntegrative Medicine(JAAIM-online).2006. Available online at:http://www.aaimedicine.com/jaaim/sep06/Blood_Sugar.pdf21.Kianbakht S, Abasi B, Perham M, Hashem Dabaghian F. Antihyperlipidemic effects of Salvia officinalis L.leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial.2011 Dec;25(12):1849-53. doi: 10.1002/ptr.3506. Epub 2011 Apr 1922.Ali Zarei, Saeed Ashtiyani, fatemeh Rasekh, Ali Asghar Mohamadi, Ayob Gabari.The effects of Physalisalkekengi extract on lipids concentrations in rats.ArakMed Univ J. 2011; 14 (2) :36-42.Available onlineat:http://amuj.arakmu.ac.ir/browse.php?a_code=A-10-430-1&slc_lang=en&sid=123.Murray RK, Rodwell VW, Bender D, et al. Harper's illustratedbiochemistry. USA: McGraw-Hill Press.2009: 250-25924.Artemis P. Simopoulos, Dun-Xian Tan, LucienC. Manchester, Russel J. Reiter.Purslane: a plant source ofomega-3 fatty acids and melatonin.J Pineal Res. 2005 Oct;39(3):331-2.PubmedPMID: 16150116.DOI:10.1111/j.1600-079X.2005.00269.x25.Xin H L, Xu YF, Yue XQ, Hou YH, Li M & Ling CQ. Analysis of chemical constituentsin extract fromPortulaca oleracea L. with GC-MS Method (In Chinese). Pharmaceut J Chin People’s Liberat. 2008;24:133–626.Sun Jv, Tepperman HM, Tepperman j. A camparison of insulin biniding by liver plasma memberane of ratsfed a high glucose diet or a high fat diet. Jlipid Res. 1977; 18(4): 533-927.Cumming JH. Nutritional implications of dietary fiber. AM J Clin Nutr. 1978; 31(10 supple): 521-9
Gatreh-Samani K, Khalili B, Rafieian M and Moradi MT. [Purslane (Portulaca oleracea) effects on serumparaoxanase-1 activity] Persian. Shahrekord Univ Med Sci J.2011; 13(1): 9-1629.Sharma A, Vijayakumar M, Rao ChV, et al. Action of Portulaca oleracea against stereptozotocin-induceoxidative stress in experimental diabetic rats. J Complement Integrat Med.2009; 6(1): 1-10
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