Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women

Authors

  • Atieh Aghapour Department of Sport Physiology,Science andResearchBranch, IslamicAzad University,Mazandaran, Iran.

Keywords:

Aerobic exercise; Chemerin; Resistin; Postmenopausal

Abstract

Background: Physical activity reduces symptoms of cardiovascular diseases. The aim of this study was to examine the effect of six-week aerobic exercise upon Chemerin and Resistin concentration in women with menopause who had hypertension.

Methods: The population of this quasi-experimental study included postmenopausal women diagnosed with hypertension. They were 50 to 55 years old and lived in Amol, a city in north part of Iran. Twenty volunteers were filled the personal consent and Health Questionnaire. They were randomly assigned to Experimental and control groups equally (n=10 per group). The experimental group conducted a 6-week aerobic training program from 8-10am every day.

Results: Endurance exercise decreased Chemerin (t=10.41, p<0.000) and Resistin (t=2.42, P<0.051); indicating the decline of inflammation and cardiovascular disease.

Conclusion: Considering anti-inflammatory effects of exercise, training plays an important role in reducing inflammatory indices in human; and endurance training can be a good strategy to deal with inflammation and cardiac- vascular risk factors.

References

Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335(8693):827–38. 7; [PubMed] [Google Scholar]

Teoman N, Ozcan A, Acar B. The effect of exercise on physical fitness and quality of life in Postmenopausal women. Maturitas. 2004;47(1):71–7. 20. [PubMed] [Google Scholar]

Casiglia Edoardo, Palatini Paolo, Da Ros Santina, Pagliara Valeria, Puato Massimo, Dorigatti Francesca, Pauletto Paolo. Effect of Blood Pressure and Physical Activity on Carotid Artery Intima–Media Thickness in Stage 1 Hypertensives and Controls. Am J Hypertens. 2000;13(12):1256–1262. [PubMed] [Google Scholar]

Orshal JM, Khalil RA. Gender, sex hormones, and vasculartone. Am J Physiol Regul Integr Comp Physiol. 2004;286(2):R233–49. [PubMed] [Google Scholar]

Chedraui P, Blumel JE, Barone G, Belzares E, Bencosme A, Calle A, et al. Impaired quality of life among middl aged women: A multicentre latino American study. Maturitas. 2004;47:71–77. [Google Scholar]

Psaltopoulou T, Orfanos P, Naska A, Lenas D, Trichopoulos D, Trichopoulou A. Prevalence, awareness, treatment and control of hypertension in a general population sample of 26,913 adults in the Greek EPIC study. Int J Epidemiol. 2004;33(6):1345–52. [PubMed] [Google Scholar]

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr, Jones DW, Materson BJ, Oparil S, Wright JT, Jr, Roccella EJ, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute. National High Blood Pressure Education Program Coordinating Committee Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206–52. [PubMed] [Google Scholar]

Kopff B, jegier A. Adipokines: adiponectin, leptin, resistin and coronary heart disease risk. Przegl lek. 2005;62(3):69–72. [PubMed] [Google Scholar]

Hoefle G, Saely CH, Risch L, Koch L, Schmid F, Rein P, Aczél S, Berchtold S, Drexel H. Relationship between the adipose-tissue hormone resistin and coronary artery disease. Clin Chim Acta. 2007;386(1–2):1–6. [PubMed] [Google Scholar]

Hansson GK. Inflammation atherosclerosis, and coronary artery disease. New engl J Med. 2005;352(16):1685–95. [PubMed] [Google Scholar]

Hackam DG, Anand ss. Emerging risk factors for atherosclerotic vascular disease:a critical review of the evidence. J American medical association (JAMA) 2003;290(7):932–40. [PubMed] [Google Scholar]

Markel H, Rocchini AP, Beekman RH, Martin J, Palmisano J, Moorehead C, Rosenthal A. Exercise-Induced Hypertension After Repair of Coarctation of the Aorta: Arm Versus Leg Exercise. J Am Coll CardioI. 1986;8(1):165–71. [PubMed] [Google Scholar]

Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brézillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med. 2003;198(7):977–85. 6. [PMC free article] [PubMed] [Google Scholar]

Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, Walder K, Segal D. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology. 2007;148(10):4687–94. [PubMed] [Google Scholar]

Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N, HERS Research Group Cardiovascular disease outcomes during 68 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERSII) J American medical association (JAMA) 2002;288(1):49–57. 3. [PubMed] [Google Scholar]

Jamurtas AZ, theocharis v, koukiulis G, stakias N, Fatouros IG, et al. the effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J appl physiol. 2006;97(1):122–6. [PubMed] [Google Scholar]

Jones TE, Basilio JL, Brophy PM, Mccammon MR, Hickner RC. Long- term exercise training in over weight adolescents improves plasma peptide YY and resistin. obesity (silver spring) 2009;17(6):1189–950. [PMC free article] [PubMed] [Google Scholar]

Bravata DM, Smith-Spangler C, Sundaram V, Gienger AL, Lin N, Lewis R, Stave CD, Olkin I, Sirard JR. Using pedometers to increase physical activity and improve health: a systematic review. J American medical association (JAMA) 2007;298(19):2296–304. 21. [PubMed] [Google Scholar]

Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307–12. 18. [PubMed] [Google Scholar]

Hughes S. Novel cardiovascular risk factors. J cardiovasc Nurs. 2003;18(2):131–8. [PubMed] [Google Scholar]

Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem. 2007;282(38):28175–88. [PubMed] [Google Scholar]

Boskabadi MH, Emad Zadeh M, Hassan Zadeh AA, Salimi N, Haji Zadeh S. Study of the level of blood pressure in subjects older than eighteen years in Mashhad. Physiology Pharmacology J. 2005;2(9):195–20. [Google Scholar]

oberbach A, Tonjes A, Kloting N, Fasshauer M, Kratzsch J, Busse MW, et al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol. 2006;154(4):77–85. [PubMed] [Google Scholar]

Kassapis C, Thompson PD. The Effects of physical Activity on Serum C- Reactive Protein and Inflammatory Markers. J Am Coll Cardiol. 2005;45:1563–1569. [PubMed] [Google Scholar]

Zhang J, Ren CX, Qi YF, Lou LX, Chen L, Zhang LK, Wang X, Tang C. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci. 2006;79(12):1153–9. 15. [PubMed] [Google Scholar]

Jessup JV, Lowenthal DT, Pollock ML, Turner T. The effects of endurance exercise training on ambulatory blood pressure in normotensive older adults. Geriatr Nephrol. 1998;8(2):103–9. [PubMed] [Google Scholar]

Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. American College of Sports Medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004;36(3):533–53. [PubMed] [Google Scholar]

Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S. Chemerin--a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun. 2007;362(4):1013–8. 3. [PubMed] [Google Scholar]

Xu W, Yu L, Zhou W, Luo M. Resistin increases lipid accumulation and CD36 expression in human macrophages. Biochem Biophys Res Commun. 2006;351(2):376–82. 15. [PubMed] [Google Scholar]

Jones TE, Basilio JL, Brophy PM, Mccammon MR, Hickner RC. Long- term exercise training in overweight a dolescents improves plasma peptide YY and resistin. obesity (silver spring) 2009;17(G):1189–950. [PMC free article] [PubMed] [Google Scholar]

Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun. 2003;309(2):286–90. 19. [PubMed] [Google Scholar]

Kim KH, Zhao L, Moon Y, Kang C, Sul HS. Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Proc Natl Acad Sci U S A. 2004;101(17):6780–5. 27. [PMC free article] [PubMed] [Google Scholar]

Konrad A, Lehrke M, Schachinger V, Seibold F, Stark R, Ochsenkühn T, Parhofer KG, Göke B, Broedl UC. Resistin is an inflammatory marker of inflammatory bowel disease in humans. Eur J Gastroenterol Hepatol. 2007;19(12):1070–4. [PubMed] [Google Scholar]

Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med. 2004;1(2):e45. [PMC free article] [PubMed] [Google Scholar]

Moreau KL, Degarmo R, Langley J, McMahon C, Howley ET, Bassett DR, Jr, Thompson DL. Increasing daily walking lowers blood pressure in postmenopausal women. Med Sci Sports Exerc. 2001;33(11):1825–31. [PubMed] [Google Scholar]

Ganderton L, Jenkins S, Gain K, Fowler R, Winship P, Lunt D, Gabbay E. Short term effects of exercise training on exercise capacity and quality of life in patients with pulmonary arterial hypertension: protocol for a randomised controlled trial. BMC Pulm Med. 2011;23:25. doi: 10.1186/1471-2466-11-25. 11. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

Crouse JH, Crouse JR, Goldbourt U, Evans G, Pinsky J, Sharrett AR, Sorlie P, Riley W, Heiss G. Risk factors and segment-specific carotid arterial enlargement in the Atherosclerosis Risk in Communities (ARIC) cohort. Stroke. 1996;27:69–75. [PubMed] [Google Scholar]

Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, Arner P, Eckel J. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes. 2009;58(12):2731–40. [PMC free article] [PubMed] [Google Scholar]

Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in over weight and obese men. Asian J Sports Med (A J M) 2010;1(3):151–8. [PMC free article] [PubMed] [Google Scholar]

Gao X, Mi S, Zhang F, Gong F, Lai Y, Gao F, Zhang X, Wang L, Tao H. Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis. Cardiovasc Diabetol. 2011;7:87. 10. [PMC free article] [PubMed] [Google Scholar]

Staffileno BA, Minnick A, Coke LA, Hollenberg SM. Blood pressure responses to lifestyle physical activity among young, hypertension-prone African-American women. J CardiovascNurs. 2007;22(2):107–17. [PubMed] [Google Scholar]

Levenstein S, Smith MW, Kaplan GA. Psychosocial predictors of hypertension in men and women. Arch Intern Med. 2001;161(10):1341–6. 28. [PubMed] [Google Scholar]

Pauletto P, Palatini P, DaRos S, Pagliara V, Santipolo N, Baccillieri S, Casiglia E, Mormino P, Pessina AC. Factors underlying the increase in carotid intima–media thickness in borderline hypertensives. Arterioscl Thromb Vasc Biol. 1999;19(5):1231–7. [PubMed] [Google Scholar]

Published

2021-12-16