Effect of diet on blood viscosity in healthy humans
A systematic revie
Keywords:
Blood Viscosity, Blood Fluidity, Diet, NutritionAbstract
Background: Increased whole blood viscosity is associated with increased risk of morbidity and mortality of several life-threatening diseases, including cardiovascular and cerebrovascular disease. The effect of diet on human health has been indicated in many studies, and a health dietary pattern can reduce the incidence of several chronic diseases. Objective: The aim of this systematic review was to assess the effect of diet on blood viscosity and related parameters such as haematocrit (HCT). Methods: This systematic review was carried out in 2017. MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials were searched from inception to 2 May 2017. We selected and included randomized clinical trials (RCTs) in the study. The inclusion criteria were articles that describe the effect of any types of local and traditional diet on blood viscosity in apparently healthy individuals. Results: Three randomized controlled trials were included in this systematic review. Different diets were used in the included trials. In one study, ingested dried–bonito broth (DBB) for four weeks, significantly reduced the blood passage time in the intervention group from 55.4±3.4 to 47.6±2.0 sec (mean ± SEM, p<0.05) compared with no significant change in the placebo group. Another study has shown significantly increased blood fluidity score in a vegetarian group in contrast to the control group after six weeks. In the last study, plasma viscosity was significantly decreased in a group which used onion–olive-oil capsules compared to the placebo group, with a highly significant difference between the two groups (p=0.0015). Conclusions: Our components of food diets may decrease blood viscosity in health status. Better and expanded methodology may improve our results.References
Mandal M. Rheology of Blood: Biophysical Significance, Measurement, Pathophysiology and
Pharmcologic Therapy. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5(6): 2165-84.
Chen G, Zhao L, Liu Y, Liao F, Han D, Zhou H. Regulation of blood viscosity in disease prevention and
treatment. Chinese Science Bulletin. 2012; 57(16): 1946-52. doi: 10.1007/s11434-012-5165-4.
Skretteberg PT, Bodegård J, Kjeldsen SE, Erikssen G, Thaulow E, Sandvik L, et al. Interaction between
inflammation and blood viscosity predicts cardiovascular mortality. Scandinavian Cardiovascular Journal.
; 44(2): 107-12. doi: 10.3109/14017430903171248. PMID: 19670036.
Cho YI, Cho DJ. Hemorheology and microvascular disorders. Korean circulation journal. 2011; 41(6): 287- 95. doi: 10.4070/kcj.2011.41.6.287. PMID: 21779279, PMCID: PMC3132688.
Li Y, Tian XX, Liu T, Wang RT. Association between whole blood viscosity and arterial stiffness in
patients with type 2 diabetes mellitus. Endocrine. 2015; 49(1): 148-54. doi: 10.1007/s12020-014-0451-3.
PMID: 25312690.
Sloop G, Holsworth Jr RE, Weidman JJ, St Cyr JA. The role of chronic hyperviscosity in vascular disease.
Therapeutic advances in cardiovascular disease. 2015; 9(1): 19-25. doi: 10.1177/1753944714553226.
PMID: 25260890.
Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Current opinion in lipidology.
; 13(1): 3-9. doi: 10.1097/00041433-200202000-00002.
Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Adherence to Mediterranean diet and health status:
meta-analysis. BMJ. 2008; 337: a1344. doi: 10.1136/bmj.a1344. PMID: 18786971, PMCID: PMC2533524.
Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan diet: health implications of a low-calorie,
nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. Journal of the American College of
Nutrition. 2009; 28(sup4): 500S-16.
Carallo C, Irace C, De Franceschi MS, Esposito T, Tripolino C, Scavelli F, et al. The effect of HDL
cholesterol on blood and plasma viscosity in healthy subjects. Clin Hemorheol Microcirc. 2013; 55(2): 223- 9. PMID: 23076003.
Campbell TC, Parpia B, Chen J. Diet, lifestyle, and the etiology of coronary artery disease: the Cornell
China study. The American journal of cardiology. 1998; 82(10): 18-21. doi: 10.1016/S0002- 9149(98)00718-8.
Higgins J, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0. The
Cochrane Collaboration. 2011; 5(0).
Nozawa Y, Ishizaki T, Kuroda M, Takahashi K, Ebihara S, Itoh T. Ingestion of dried-bonito broth
ameliorates blood fluidity in humans. Journal of health science. 2007; 53(5): 543-51. doi:
1248/jhs.53.543.
Ernst E, Franz A. Blood fluidity score during vegetarian and hypocaloric diets - a pilot study.
Complementary Therapies in Medicine. 1995; 3(2): 70-1. doi: 10.1016/S0965-2299(95)80002-6.
Kalus U, Pindur G, Jung F, Mayer B, Radtke H, Bachmann K, et al. Influence of the onion as an essential
ingredient of the Mediterranean diet on arterial blood pressure and blood fluidity. Arzneimittelforschung.
; 50(09): 795-801. PMID: 11050695
Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, et al. Origins and evolution of the
Western diet: health implications for the 21st century. Am J Clin Nutr. 2005; 81(2): 341-54. PMID:
Hitsumoto T. Factors affecting impairment of blood rheology in obese subjects. Journal of cardiology.
; 60(5): 401-6. doi: 10.1016/j.jjcc.2012.06.012. PMID: 22884686.
Floros JD, Newsome R, Fisher W, Barbosa‐Cánovas GV, Chen H, Dunne CP, et al. Feeding the world
today and tomorrow: the importance of food science and technology. Comprehensive Reviews in Food
Science and Food Safety. 2010; 9(5): 572-99. doi: 10.1111/j.1541-4337.2010.00127.x.
Peters SA, Woodward M, Rumley A, Tunstall-Pedoe HD, Lowe GD. Plasma and blood viscosity in the
prediction of cardiovascular disease and mortality in the Scottish Heart Health Extended Cohort Study. Eur
J Prev Cardiol. 2017; 24(2): 161-7. doi: 10.1177/2047487316672004. PMID: 27798361.
Okahara S, Soh Z, Miyamoto S, Takahashi H, Itoh H, Takahashi S, et al. A Novel Blood Viscosity
Estimation Method Based on Pressure‐Flow Characteristics of an Oxygenator During Cardiopulmonary
Bypass. Artificial Organs. 2017; 41(3): 262-6. doi: 10.1111/aor.12747.
Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, et al. Oxidative stress, prooxidants, and
antioxidants: the interplay. BioMed research international. 2014; 2014. doi: 10.1155/2014/761264.
Kim KA, Yim JE. Antioxidative activity of onion peel extract in obese women: a randomized, double- blind, placebo controlled study. J Cancer prev. 2015; 20(3): 202. doi: 10.15430/JCP.2015.20.3.202. PMID:
, PMCID: PMC4597809.
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense.
World Allergy Organ J. 2012; 5(1): 9. doi: 10.1097/WOX.0b013e3182439613. PMID: 23268465, PMCID:
PMC3488923.
Gyawali P, Richards RS. Association of altered hemorheology with oxidative stress and inflammation in
metabolic syndrome. Redox Report. 2015; 20(3): 139-44. doi: 10.1179/1351000214Y.0000000120. PMID:
Seki K, Sumino H, Nara M, Ishiyama N, Nishino M, Murakami M. Relationships between blood rheology
and age, body mass index, blood cell count, fibrinogen, and lipids in healthy subjects. Clinical
hemorheology and microcirculation. 2006; 34(3): 401-10. PMID: 16614464.
Okita M, Sasagawa T, Kotani M, Hayashi M, Yamashita H, Kimoto M, et al. Green vegetable juice
increases polyunsaturated fatty acid of erythrocyte membrane phospholipid in hypercholesterolaemic
patients. Asia Pacific journal of clinical nutrition. 2000; 9(4): 309-13. doi: 10.1046/j.1440- 6047.2000.00161.x. PMID: 24394508.
Kasperczyk A, Słowińska-Łożyńska L, Dobrakowski M, Zalejska-Fiolka J, Kasperczyk S. The effect of
lead-induced oxidative stress on blood viscosity and rheological properties of erythrocytes in lead exposed
humans. Clin Hemorheol Microcirc. 2014; 56(3): 187-95. PMID: 23370159.
Al-Snafi AE. Therapeutic properties of medicinal plants: a review of plants with hypolipidemic,
hemostatic, fibrinolytic and anticoagulant effects (part 1). Asian Journal of Pharmaceutical Science &
Technology. 2015; 5(4): 271-84.
Bisen PS, Emerald M. Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.). Current
Nutrition & Food Science. 2016; 12(3): 190-9. doi: 10.2174/1573401312666160608121954.
Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. Am J Clin Nutr. 2003;
(3): 544S-51. doi: 10.1093/ajcn/78.3.544S. PMID: 12936948.
Cicha I, Suzuki Y, Tateishi N, Maeda N. Effects of dietary triglycerides on rheological properties of human
red blood cells. Clinical hemorheology and microcirculation. 2004; 30(3,4): 301-5.
Ramos-Escudero F, Morales MT, Asuero AG. Characterization of bioactive compounds from monovarietal
virgin olive oils: relationship between phenolic compounds-antioxidant capacities. International Journal of
Food Properties. 2015; 18(2): 348-58. doi: 10.1080/10942912.2013.809542.
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