Nutrichemistry, a means of preventing and healing chronic diseases

Authors

  • Joseph Kajima Mulengi Laboratory of Organic Chemistry, Natural Products and Analysis, University of Tlemcen

Keywords:

Heart diseases, Cancer, Chronic diseases, Diabetes

Abstract

The burden of chronic diseases, such as cancer, diabetes, heart disease, and hypertension is so heavy that health care systems' provisions are hampered in many countries. The high incidence of chronic diseases might be mainly explained through poor diets and detrimental conditions of lifestyle. A distinct insight on healing and preventing those diseases will be described in this short review, which includes our own work. 

References

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, et al. Bactericidal

Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells. Sci Transl

Med. 2013; 5(192): 192ra85. doi: 10.1126/scitranslmed.30006055. PMID: 23825301, PMCID:

PMC3760005.

Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am Med J. 1998;

(1B): 31S-8S. doi: 10.1016/S0002-9343(98)00072-2. PMID: 9715832.

Krijthe BP, Heeringa J, Hofman A, Franco OH, Stricker BH. Stricker Non-steroidal anti-inflammatory

drugs and the risk of atrial fibrillation: a population-based follow-up study. BMJ Open. 2014; 4(4):

e004059. doi: 10.1136/bmjopen-2013-004059. PMID: 24713211, PMCID: PMC3987714.

Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, et al. Effect of ezetimibe and/or

simvastatin on coenzyme Q10 levels in plasma: a randomised trial. Drug Saf. 2006; 29(8): 703-12. doi:

2165/00002018-200629080-00007. PMID: 16872244.

Nahin RL, Barnes PM, Stussman BJ. Expenditures on Complementary Health Approaches: United States,

Natl Health Stat Report. 2016; (95): 1-11. PMID: 27352222.

Watson CS, Jeng YJ, Guptarak J. Endocrine disruption via estrogen receptors that participate in

nongenomic signaling pathways. J Steroid Biochem Mol Biol. 2011; 127(1-2): 44-50. doi:

1016/j.jsbmb.2011.01.015. PMID: 21300151, PMCID: PMC3106143.

Church GM. Church Precision chemistry for Precision Medicine. ACS Cent Sci. 2015; 1(1): 11-3. doi:

1021/acscentsci.5b00088. PMID: 27162939, PMCID: PMC4827659.

The Office of Disease Prevention and Health Promotion (ODPHP). Scientific Report of the 2015 Dietary

Guidelines Advisory Committee. 2014.

Franz MJ, VanWormer JJ, Crain AL, Boucher JL, Histon T, Caplan W, et al. Weight-Loss Outcomes: A

Systematic Review and Meta-Analysis of Weight-Loss Clinical Trials with a Minimum 1-Year Follow-Up.

J Am Diet Assoc. 2007; 107(10): 1755-67. doi: 10.1016/j.jada.2007.07.017. PMID: 17904936.

Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes:

normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.

Diabetologia. 2011; 54(10): 2506-14. doi: 10.1007/s00125-011-2204-7. PMID: 21656330, PMCID:

PMC3168743.

DiNicolantonio JJ, O'Keefe JH, Lucan SC. Added Fructose: A Principal Driver of Type 2 Diabetes Mellitus

and Its Consequences. Mayo Clin Proc. 2015; 90(3): 372-81. doi: 10.1016/j.mayocp.2014.12.019. PMID:

Dhurandhar NV, Thomas D. The link between dietary sugar intake and cardiovascular disease mortality.

An unresolved question. JAMA. 2015; 313(9): 959-60. doi: 10.1001/jama.2014.18267. PMID: 25734737.

de Lorgeril M. Cholestérol, mensonges et propaganda. Thierry Souccar Editions; 2008.

Health.gov. Dietary guidelines for Americans 2015-2020. Science base Chapter: Food and nutrients

intakes, and Health: Currents status and trends. 2014.

Health.gov. Dietary Guidelines. 2015. Available from; http://health.gov/dietaryguidelines.

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the

association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010; 91(3): 535-46. doi:

3945/ajcn.2009.27725. PMID: 20071648, PMCID: PMC2824152.

Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J

Clin Nutr. 2010; 91(3); 502-9. doi: 10.3945/ajcn.2008.26285. PMID: 20089734, PMCID: PMC2824150.

Mercola. Why Conventional Recommendations for Those at High Risk for Heart Disease Usually Makes

Matters Worse. August 02, 2015. Available from:

http://articles.mercola.com/sites/articles/archive/2015/08/02/heart-disease-risk-factors.aspx.

Diamond DM, Ravnskov U. How statistical deception created the appearance that statins are safe and

effective in primary and secondary prevention of cardiovascular disease. Expert Rev Clin Pharmacol. 2015;

(2): 201-10. doi: 10.1586/17512433.2015.1012494. PMID: 25672965.

Ober C, Sinatra ST, Zucker M. Earthing: the most important health discovery ever? Top of the World Drive

Laguna Beach, CA: Basic Health Publications; 2010. ISBN: 978-1-59120-283-7 28812.

Ried K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and

Stimulates Immunity: An Updated Meta-analysis and Review. J Nutr. 2016; 146(2): 389S-96S. doi:

3945/jn.114.202192. PMID: 26764326.

Rahman K, Lowe GM, Smith S. Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering

Intracellular Signaling and Platelet Shape Change. J Nutr. 2016; 146(2): 410S-5S. doi:

3945/jn.114.202408. PMID: 26764324.

Matsumoto S, Nakanishi R, Li D, Alani A, Rezaeian P, Prabhu S, et al. Aged Garlic Extract Reduces Low

Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective

Randomized Double-Blind Study. J Nutr. 2016; 146(2): 427S-32S. doi: 10.3945/jn.114.202424. PMID:

Christofferson T. Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a

New and Hopeful Path to a Cure. South Carolina, USA: CreateSpace; 2014. ISBN-13: 978-1500600310.

Barry J, Fritz M, Brender JR, Smith PE, Lee DK, Ramamoorthy A. Determining the effects of lipophilic

drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am

Chem Soc. 2009; 131(12): 4490-8. doi: 10.1021/ja809217u. PMID: 19256547, PMCID: PMC2748423.

Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, et al. Multitargeting by curcumin as

revealed by molecular interaction studies. Nat Prod Rep. 2011; 28: 1937-55. doi: 10.1039/c1np00051a.

PMID: 21979811, PMCID: PMC3604998.

Hucklenbroich J, Klein R, Neumaier B, Graf R, Fink GR, Schroeter M, et al. Aromatic-turmerone induces

neural stem cell proliferation in vitro and in vivo. Stem Cell Research & Therapy. 2014; 5:100-9.

Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of

action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006; 54(11):

-64. doi: 10.1002/art.22180. PMID: 17075840.

Sayer JI. 600 Reasons Turmeric May Be The World's Most Important Herb. GreenMedinfo. 2014.

Chandru H, Sharada AC, Bettadaiah BK, Kumar CS, Rangappa KS, Sunila, et al. In vivo growth inhibitory

and anti-angiogenic effects of synthetic novel cyclopropoxy curcumin analogs on mouse Ehrlich ascites

tumor. Bioorg Med Chem. 2007; 15(24): 7696-703. doi: 10.1016/j.bmc.2007.08.051. PMID: 17869527.

Lee KH, Ab Aziz FH, Syahida A, Abas F, Shaari K, Israf DA, et al. Synthesis and biological evaluation of

curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.

Eur J Med Chem. 2009; 44(8): 3195-200. doi: 10.1016/j.ejmech.2009.03.020. PMID: 19359068.

Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkaya S, Camalier RF, et al. Synthesis and biological

evaluation of novel curcumin analogs as anti-cancer and antiangiogenesis agents. Bioorg Med Chem. 2004;

(14): 3871-83. doi: 10.1016/j.bmc.2004.05.006. PMID: 15210154.

Azorín-Ortuño M, Yañéz-Gascón MJ, Pallarés FJ, Rivera J, González-Sarrías A, Larrosa M, et al. A

Dietary Resveratrol-Rich Grape Extract Prevents the Developing of Atherosclerotic Lesions in the Aorta of

Pigs Fed an Atherogenic Diet. J Agric Food Chem. 2012; 60(22): 5609-20. doi: 10.1021/jf301154q. PMID:

Cheng TH, Liu JC, Lin H, Shih NL, Chen YL, Huang MT, et al. Inhibitory effect of resveratrol on

angiotensin II-induced cardiomyocyte hypertrophy. Naunyn Schmiedebergs Arch Pharmacol. 2004; 369(2):

-44. doi: 10.1007/s00210-003-0849-6. PMID: 14663554.

Paul S, Rimando AM, Lee HJ, Ji Y, Reddy BS, Suh N. Anti-inflammatory Action of Pterostilbene Is

Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells. Cancer Prev

Res (Phila). 2009; 2(7): 650-7. doi: 10.1158/1940-6207.CAPR-08-0224. PMID: 19549798, PMCID:

PMC2753521.

Al Shukor N, Van Camp J, Gonzales GB, Staljanssens D, Struijs K, Zotti MJ, et al. Angiotensin- Converting Enzyme Inhibitory Effects by Plant Phenolic Compounds: A Study of Structure Activity

Relationships. J Agric Food Chem. 2013; 61(48): 11832-9. doi: 10.1021/jf404641v. PMID: 24219111.

Hamdan L, Arrar Z, Al Muataz Y, Suleiman L, Négrier C, Mulengi JK, et al. Alpha Cyano-4-Hydroxy-3- Methoxycinnamic Acid Inhibits Proliferation and Induces Apoptosis in Human Breast Cancer Cells. PLOS

ONE. 2013; 8(9): e72953. doi: 10.1371/journal.pone.0072953. PMID: 24039831, PMCID: PMC3764168.

Pedersen PL. The cancer cell’s power plants as promising therapeutic targets: an overview. J Bioenerg

Biomembr. 2007; 39(1): 1-12. doi: 10.1007/s10863-007-9070-5. PMID: 17404823.

Ko YH, Pedersen PL, Geschwind JF. Glucose catabolism in the Rabbit VX2 tumor model for liver cancer:

characterization and targeting hexokinase. Cancer Lett. 2001; 173: 83-91. doi: 10.1016/S0304- 3835(01)00667-X.

Published

2022-01-18

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