Morphology of the corpus callosum and schizophrenia
A case-control study in Kashan, Iran
Keywords:
Corpus Callusum, Schizophrenia, MRI, Positive and Negative Syndrome ScaleaAbstract
Background: Corpus Callosum (CC) plays a significant role in hemispheric communication and in lateralized brain function and behaviors. Structural abnormalities in the corpus callosum of schizophrenic patients were reported. However, previous studies regarding the relationship between morphology of CC in patients with schizophrenia and healthy people are controversial.
Objective: To evaluate the morphological differences of the CC between patients with chronic schizophrenia and healthy people and to examine the relationship between the characteristics of the CC and schizophrenia severity.
Methods: This cross-sectional study was conducted on 63 patients with chronic schizophrenia (the case group) referred to Kargarnezhad Psychiatric Hospital in Kashan, Iran, and 63 healthy people (the control group) between January 2013 and December 2014. All participants underwent brain magnetic resonance imaging. Shape, anteroposterior length, and area of the CC were measured and compared in both groups. The severity of the symptoms occurring in patients with schizophrenia was evaluated using the positive and negative syndrome scale. In this study, we employed Chi-square test, t-test, Pearson product-moment correlation coefficient test, bivariate analysis of variance and logistic regression were used to test the association between different variables using SPSS software version 20.
Results: Results showed that the most common shape of the CC in each group was splenial bulbosity. The length and area of the CC in patients with schizophrenia were less than those of the control group and were greater in men compared with women in both groups. Although there was a significant difference in the surface area of the CC between the schizophrenic and control groups (p<0.001), no significant difference was seen regarding the anteroposterior length of CC (p=0.75). Moreover, a significant correlation was found between the surface area and anteroposterior length of the CC (p<0.001 and p<0.014, respectively).
Conclusions: Morphologic characteristics of the CC can be helpful to anticipate schizophrenia especially in patients’ family, and it can be used for suitable and faster treatment to prevent progressive cognitive dysfunction.
References
Luders E, Thompson PM, Toga AW. The development of the corpus callosum in the healthy human brain.
J Neurosci. 2010; 30(33): 10985-90. doi: 10.1523/JNEUROSCI.5122-09.2010. PMID: 20720105, PMCID:
PMC3197828.
Luders E, Thompson PM, Narr KL, Zamanyan A, Chou YY, Gutman B, et al. The link between callosal
thickness and intelligence in healthy children and adolescents. Neuroimage. 2011; 54(3): 1823-30. doi:
1016/j.neuroimage.2010.09.083. PMID: 20932920, PMCID: PMC3110814.
Frazier TW, Hardan AY. A meta-analysis of the corpus callosum in autism. Biol Psychiatry. 2009; 66(10):
-41. doi: 10.1016/j.biopsych.2009.07.022. PMID: 19748080, PMCID: PMC2783565.
Innocenti GM, Ansermet F, Parnas J. Schizophrenia, neurodevelopment and corpus callosum. Mol
Psychiatry. 2003; 8(3): 261-74. doi: 10.1038/sj.mp.4001205. PMID: 12660799.
Narr KL, Thompson PM, Sharma T, Moussai J, Cannestra AF, Toga AW. Mapping morphology of the
corpus callosum in schizophrenia. Cereb Cortex. 2000; 10(1): 40-9. doi: 10.1093/cercor/10.1.40. PMID:
Paul LK, Brown WS, Adolphs R, Tyszka JM, Richards LJ, Mukherjee P, et al. Agenesis of the corpus
callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci. 2007; 8(4):
-99. doi: 10.1038/nrn2107. PMID: 17375041.
Renteria ME. Cerebral asymetry: a quantitative, multifactorial, and plastic brain phenotype. Twin Res Hum
Gent. 2012; 15(3): 401-13. doi: 10.1017/thg.2012.13. PMID: 22856374.
Mitchell RL, Crow TJ. Right hemispher language functions and schizophrenia: the forgotten hemispher?
Brain. 2005; 128(Pt 5): 963-78. doi: 10.1093/brain/awh466. PMID: 15743870.
Ribolsi M, Daskalakis ZJ, Siracusano A, Koch G. Abnormal asymmetry of brain connectivity in
schizophrenia. Front Human Neuroscience. 2014; 8: 1010. doi: 10.3389/fnhum.2014.01010. PMID:
, PMCID: PMC4273663.
Corbalis MC. Left brain right brain: facts and fantasies. PLoS Biol. 2014; 12(1): e1001767. doi:
1371/journal.pbio.1001767. PMID: 24465175, PMCID: PMC3897366.
Cai Q, Vander haegen L, Brysbaert M. Complementary hemispheric spacialization for language production
and visuspatial attention. Proc Natl Acad Sci U S A. 2013; 110(4): 322-30. doi: 10.1073/pnas.1212956110.
PMID: 23297206, PMCID: PMC3557046.
Dundas EM, Plaut DC, Behrmann M. An ERP investigation of the co-development of hemispheric
lateralization of face and word recognition. Neuropsychologia. 2014; 61: 315-23. doi:
1016/j.neuropsychologia.2014.05.006. PMID: 24933662, PMCID: PMC4251456.
Sommer IE, Ramsy NF, Kahn RS. Language lateralization in schizophrenia, an fMRI study. schizophr Res.
; 52(1-2): 57-67. PMID: 11595392.
Sommer I, Ramsey N, Kahn R, Aleman A, Bouma A. Handedness, language lateralizationand anatomical
asymmetry in schizophrenia: meta analysis. Br J psychiatry. 2001; 178: 344-51. doi:
1192/bjp.178.4.344. PMID: 11282814.
Sommer IE, Ramsey NF, Mandl RC, Kahn RS. Language lateralization infemale patients with
schizophrenia, an fMRI study. schizophr res. 2003; 60(2-3): 183-90. PMID: 12591582.
Sommer IE, Ramsey NF, Mandl RC, van Oel CJ, Kahn RS. Language activation in monozygotic twins
discordant for schizophrenia. Biol Psychiatry. 2004; 184: 128-35. PMID: 14754824.
Bleich-Cohen M, Handler T, Kotler M, Strous RD. Reduced language lateralization in first-episode
schizophrenia: an fMRI index of functional asymmetry. Psychiatry Res. 2009; 171(2): 82-93. doi:
1016/j.pscychresns.2008.03.002. PMID: 19185468.
Kozlovskiy S, Vartanov AV, Pyasik M, Nikonova E. Functional role of corpus callosum regiones in human
memory functioning. International journal of psycophisiology. 2012; 85(3): 396-7. doi:
1016/j.ijpsycho.2012.07.092.
Peterson BS, Feineigle PA, Staib LH, Gore JC. Automated measurement of latent morphological features
in the human corpus callosum. Hum Brain Mapp. 2001; 12(4): 232-45. PMID: 11241874.
Arnone D, McIntosh AM, Tan GM, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of
the corpus callosum in schizophrenia. Schizophr Res. 2008; 101(1-3): 124-32. doi:
1016/j.schres.2008.01.005. PMID: 18289833.
John JP, Shakeel MK, Jain S. Corpus callosal area differences and gender dimorphism in neuroleptic- naı¨ve, recent-onset schizophrenia and healthy control subjects. Schizophr Res. 2008; 103(1-3): 11-21. doi:
1016/j.schres.2008.04.035. PMID: 18585006, PMCID: PMC2605782.
Bersani G, Quartini A, Iannitelli A, Paolemili M, Ratti F, Di Biasi C, et al. Corpus callosum abnormalities
and potential age effect in men with schizophrenia: an MRI comparative study. Psychiatry Res. 2010;
(2): 119-25. doi: 10.1016/j.pscychresns.2010.04.011. PMID: 20599365.
Downhill JE Jr, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, et al. Shape and size
of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr Res. 2000; 42(3):
-208. PMID: 10785578.
Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Morphology of the corpus
callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness. Br J
Psychiatry. 2008; 192(6): 429-34. doi: 10.1192/bjp.bp.107.041251. PMID: 18515892.
Keller A, Jeffries NO, Blumenthal J, Clasen LS, Liu H, Giedd JN, et al. Corpus callosum development in
childhood-onset schizophrenia. Schizophr Res. 2003; 62(1-2): 105-14. PMID: 12765750.
Walterfang M, Yung A, Wood AG, Reutens DC, Phillips L, Wood SJ, et al. Corpus callosum shape
alterations in individuals prior to the onset of psychosis. Schizophr Res. 2008; 103(1-3): 1-10. doi:
1016/j.schres.2008.04.042. PMID: 18562178.
Panizzon MS, Hoff AL, Nordahl TE, Kremen WS, Reisman B, Wieneke M, et al. Sex differences in the
corpus callosum of patients with schizophrenia. Schizophr Res. 2003; 62(1-2): 115-22. PMID: 12765751.
Ardekani BA, Figarsky K, Sidtis JJ. Sexual dimorphismin human corpus callosum: an MRI study using the
OASIS brain database. Cerebral cortex. 2012; 23(10): 2514-120. doi: 10.1093/cercor/bhs253. PMID:
, PMCID: PMC3767965.
Sadock B. Kaplan & Sadock Comprehensive text book of psychiatry. 9th ed. 2009.
Balevich EC, Haznedar MM, Wang E, Newmark RE, Bloom R, Schneiderman JS, et al. Corpus callosum
size and diffusion tensor anisotropy in adolescents and adults with schizophrena. Psychiatry Res. 2015;
(3): 244-51. doi: 10.1016/j.pscychresns.2014.12.005. PMID: 25637358, PMCID: PMC4363270.
Walterfang M, Wood AG, Reutens DC, Wood SJ, Chen J, Velakoulis D, et al. Corpus callosum size and
shape in first-episode affective and schizophrenia-spectrum psychosis. psychiatry Res. 2009; 173(1): 77-82.
doi: 10.1016/j.pscychresns.2008.09.007. PMID: 19447585.
Bachmann S, Pantel J, Flender A, Bottmer C, Essig M, Schröder J. Corpus callosum in first-episode
patients with schizophrenia-a magnetic resonance imaging study. Psychol Med. 2003; 33(6): 1019-27.
PMID: 12946086.
Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of
the corpus callosum in first-episode, treatment naı¨ve schizophrenia. J Neurol Neurosurg Psychiatry. 2002;
(6): 757-60. PMID: 12023420, PMCID: PMC1737922.
Gupta T, Singh B, Kapoor K, Gupta M, Kochhar S. Age and sex related variations in corpus callosal
morphology. Nepal Med Coll J. 2008; 10(4): 215-21. PMID: 19558056.
Luder E, Narr KL, Zaidel E, Thampson PM, Toga AW. Gender effects on callosal thickness in scaled and
unscaled space. Neuroreport. 2006; 17(11): 1103-6. doi: 10.1097/01.wnr.0000227987.77304.cc. PMID:
Tuncer MC, Hatipoglu ES, Osates M. sexual dimophisms and handedness in the human corpus callusum
based on magnetic resonance imaging. Surg Radial anat. 2005; 27(3): 254-9. doi: 10.1007/s00276-004- 0308-1. PMID: 15682276.
Woodruff PW, McManus IC, David AS. Meta-analysis of corpus-callosum size in schizophrenia. J Neurol
Neurosurg Psychiatr. 1995; 58(4): 457-61. PMID: 7738554, PMCID: PMC1073433.
Colinson SL, Gan SC, Woon PS, Kuswanto C, Sum MY, Yang GL, et al. Corpus callosum morphology in
first-episode and chronic schizophrenia: combined magnetic resonance and diffusion tensor imaging study
of chinese Singaporean patients. B J Psych. 2014; 204(1): 55-60. doi: 10.1192/bjp.bp.113.127886. PMID:
Frumin M, Golland P, Kikinis R, Hirayasu Y, Salisbury DF, Hennen J, et al. Shape Differences in the
corpus callosum in First-Episode schizophrenia and First-Episode Psychotic Affective Disorder. Am J
Psychiatry. 2002; 159(5): 866-8. doi: 10.1176/appi.ajp.159.5.866. PMID: 11986146, PMCID:
PMC2845853.
Jiang H, van Zijl PC, Kim J, Pearlson GD, Mori S. resource program for diffusion tensor computation and
fiber bundle tracking. Comput Methods Programs Biomed. 2006; 81)2): 106-16. doi:
1016/j.cmpb.2005.08.004. PMID: 16413083.
Mitelman SA, Nikiforova YK, Canfield EL, Hazlett EA, Brickman AM, Shihabuddin L, et al. A
longitudinal study of the corpus callosum in chronic schizophrenia. Schizophr Res. 2009; 114(1-3): 144-53.
doi: 10.1016/j.schres.2009.07.021. PMID: 19713080, PMCID: PMC2763416.
Suganthy J, Raghuram L, Antonisamy B, Vettivel S, Madhavi C, Koshi R. Gender-and age-related
differences in the morphology of the corpus callosum. Clin Anat. 2003; 16(5): 396-403. doi:
1002/ca.10161. PMID: 12903061.
Mourgela S, Anagnostopoulou S, Sakellaropoulos A, Gouliamos A. An MRI study of sex-and age-related
differences in the dimensions of the corpus callosum and brain. Neuroanatomy. 2007; 6(1): 63-5.
Driesen NR, Raz N. The influence of sex, age, and handedness on corpus callosum morphology: a meta- analysis. Psychobiology. 1995; 23(3): 240-7.
Jancke L, Staiger JF, Schlaug G, Huang Y, Steinmetz H. The relationship between corpus callosum size
and forebrain volume. Cereb Cortex. 1997; 7(1): 48-56. doi: 10.1093/cercor/7.1.48. PMID: 9023431.
Takeda S, Hirashima Y, Ikeda H, Yamamoto H, Sugino M, Endo S. Determination of indices of the corpus
callosum associated with normal aging in Japanese individuals. Neuroradiol. 2003; 45(8): 513-8. doi:
1007/s00234-003-1019-8. PMID: 12879325.
Murphy DG, Decarli C, McIntosh AR, Daly E, Mentis MJ, Pietrini P, et al. Sex diffrences in human brain
morphometry and metabulism: an in vivo quantitative magnetic resonance imaging and positron emission
tomography study on the effect of aging. Arch Gen psychitry. 1996; 53(7): 585-94. doi:
1001/archpsyc.1996.01830070031007. PMID: 8660125.
Meng Y, Zhang X. Transcallosal Connectivity Changes from Infancy to Late Adulthood: An Ex-vivo
Diffusion Spectrum Imaging Study of Macaque Brains. Brain Connect. 2015; 5(3): 147-55. doi:
1089/brain.2014.0285. PMID: 25389564, PMCID: PMC4394181.
Smith k, Kubiki m, Donnell LO, Westin CF, Niznikiewicz M, McCarley R, et al. Automatic cluster
analysis of corpus callosum subdivisions in schizophrenia: A diffusion tensor imaging study. schizophrenia
research. 2006; 94.
Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R. Incidental subcortical lesions identified on
magnetic resononce imaging in the elderly. Correlation with age and cerebrovascular factors. Stroke. 1986;
(6): 1084-9. PMID: 3810705.
Downhill JE Jr, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, et al. Shape and size
of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr Res. 2000; 42(3):
-208. PMID: 10785578.
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