Pattern of childhood brucellosis in Najran, south Saudi Arabia in 2013-2017

Authors

  • Ghadi Mohammed Al Hashan Medical Intern, Najran University, Najran, Kingdom of Saudi Arabia

Keywords:

Brucellosis, Najran, Saudi Arabia

Abstract

Background: With more than 500,000 new cases annually, human brucellosis is the commonest zoonotic disease worldwide. In some endemic countries, its prevalence is more than 10 per 100,000 population.

Objective: The aim of this study was to determine the magnitude of the problem and the clinical features, laboratory findings, treatment given and complications seen in children with brucellosis in Najran City, Kingdom of Saudi Arabia. 

Methods: This is a case-series study by analysis of data of children known or diagnosed to have brucellosis for the last 4 years in Najran City. Data was obtained by reviewing the hospital records of the Maternity and Children Hospital and Najran Armed Forces Hospital in Najran during the period from 2013 to 2017. The statistical analysis was carried out using SPSS version 16.0. Since it was the first report of brucellosis on the study population, we used descriptive statistics (frequency, proportion, mean, and standard deviation) for presenting the findings.

Results: We studied 57 diagnosed cases of child brucellosis throughout the past 4 years in Najran, south Saudi Arabia with an average number of about 12 cases per year. Of the cases, 15.8% reported a history of ingestion of raw milk and dairy product and only 1.8% of them reported a history of animal contact while 82.4% confirmed unknown mode of transmission. Fever was the only finding in 36.8%, fever and arthralgia 21.1%, and fever and myalgia 19.3%. Two thirds of the cases were diagnosed by standard agglutination test (SAT). Hepatosplenomegaly was found in 10.5%. Rifampicin was the antibiotic of choice and 70.2% of cases have been cured but 3.5% relapsed and 1.8% died from complications. 

Conclusions: Results suggest brucellosis be considered in every child living in an endemic area, showing symptoms of fever and having a history of ingestion of raw milk and dairy product and/or animal contact.

Prevention should rely on health education of the public about different issues of the disease including boiling raw milk.

References

Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and

complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J

Infect Dis. 2010; 14(6): e469-78. doi: 10.1016/j.ijid.2009.06.031. PMID: 19910232.

Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005; 352: 2325-36. doi:

1056/NEJMra050570.

Kambal AM, Maghoub ES, Jamjoon GA, Chawdhury MNH. Brucellosis in Riyadh, Saudi Arabia:

amicrobiological and clinical study. Trans R Soc Trop Med Hyg. 1983; 77(6): 820-4. doi: 10.1016/0035- 9203(83)90297-3. PMID: 6665836.

Madkour MM, Rahman A, Mohamed E, Talukder MA, Kudwah AJN. Brucellosis in Saudi Arabia. Saudi

Med J. 1985; 6: 324-32. doi: 10.5144/0256-4947.1999.403.

Al-Zeftawi NM, Al-Issa M, Bekairi SI, Radwan AI, Hafez SM. Epidemiology of Brucellosis among

abattoir workers in Saudi Arabia. Ann Saudi Med. 1986; 6: S29-31. doi: 10.1177/146642409311300503.

Shaalan MA, Memish ZA, Mahmoud SA, Alomari A, Khan MY, Almuneef M, et al. Brucellosis in

children: clinical observations in 115 cases. Int J lnfec Dis. 2002; 6(3): 182-6. PMID: 12718832.

Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new globalmap of human brucellosis.

Lancet Infect Dis. 2006; 6(2): 91-9. doi: 10.1016/S1473-3099(06)70382-6. PMID: 16439329.

Gül S, Satilmiş ÖK, Ozturk B, Gökçe Mİ, Kuscu F. Seroprevalence of Brucellosis among Children in the

Middle Anatolia Region of Turkey. J Health Popul Nutr. 2014; 32(4): 577-9. PMID: 25895189, PMCID:

PMC4438686.

El-Koumi MA, Afify M, Al-Zahrani SH. A Prospective Study of Brucellosis in Children: Relative

Frequency of Pancytopenia. Mediterr J Hematol Infect Dis. 2013; 5(1): e2013011. doi:

4084/MJHID.2013.011. PMID: 23505599, PMCID: PMC3591276.

Briones-Lara E, Palacios-Saucedo Gdel C, Martínez-Vázquez IO, Morales-Loredo A, Bilbao-Chávez Ldel

P. [Response to the treatment of brucellosis among children. Evaluation with Huddleson reaction and

PCR]. Rev Med Inst Mex Seguro Soc. 2007; 45(6): 615-22. PMID: 18593545.

Al-Eissa YA. Brucellosis in Saudi Arabia: Past, present and future. Ann Saudi Med. 1999; 19(5): 403-5.

doi: 10.5144/0256-4947.1999.403. PMID: 17277503.

Benjamin B, Annobil SH. Childhood brucellosis in southwestern Saudi Arabia: a 5-year experience. J Trop

Pediatr. 1992; 38(4): 167-72. doi: 10.1093/tropej/38.4.167. PMID: 1527811.

Bosilkovski M, Krteva L, Caparoska S, Labacevski N, Petrovski M. Childhood brucellosis: Review of 317

cases. Asian Pac J Trop Med. 2015; 8(12): 1027-32. doi: 10.1016/j.apjtm.2015.11.009. PMID: 26706674.

Andriopoulos P, Tsironi M, Deftereos S, Aessopos A, Assimakopoulos G. Acute brucellosis: presentation,

diagnosis, and treatment of 144 cases. Int J Infect Dis. 2007; 11(1): 52-7. doi: 10.1016/j.ijid.2005.10.011.

PMID: 16651018.

Mantur BG, Akki AS, Mangalgi SS, Patil SV, Gobbur RH, Peerapur BV. Childhood brucellosis--a

microbiological, epidemiological and clinical study. J Trop Pediatr. 2004; 50(3): 153-7. doi: 10.4103/0255- 0857.34758. PMID: 15233191.

Fallatah SM, Oduloju AJ, Al-Dusari SN, Fakunle YM. Human brucellosis in Northern Saudi Arabia. Saudi

Med J. 2005; 26(10): 1562-6. PMID: 16228056.

Published

2022-02-12