The Axis “Human Papillomavirus - Anal Squamous Cell Carcinoma”: A Review

Résumé

Background: Anal Squamous Cell Carcinoma (ASCC) is an infrequent neoplasia that represents 2% of the digestive tumors and it has a growing incidence.

Objective: This investigation (i) studies the pathogenesis of an increasingly prevalent disease, (ii) its treatment and prognosis along with (iii) a bibliographical review of the main characteristics of the Human Papillomavirus (HPV) as well as its effects on humans.

Methods: A literature review is performed, comprising articles up to 2019 and cross-research manuscripts with the initial research.

Results: Several studies demonstrate the HPV role as a significant risk factor to the development of ASCC, as well as its higher incidence in HIV-positive individuals and in those who engage in receptive anal intercourse. Future trends in theragnostic using information technology are examined.

Conclusions: ASCC is a neoplasm mostly associated with HPV. Many studies are needed to improve the treatment as well as in the evaluation of the tumor characteristics.