Polymorphism rs3087243 is associated with the occurrence of ankylosing spondylitis in the West Algerian population

  • Chahinez Amira DAHMANI Laboratoire de Génétique Moléculaire et Cellulaire LGMC, Université des sciences et de la technologie d'Oran Mohamed Boudiaf USTOMB
  • Ahmed BENZAOUI Service de Rheumatologie, Centre Hospitalo Universitaire d'Oran CHU
  • Fatima Zohra SEDIKI Laboratoire de Génétique Moléculaire et Cellulaire LGMC, Université des sciences et de la technologie d'Oran Mohamed Boudiaf USTOMB
  • Leila ADDA NEGGAZ Laboratoire de Génétique Moléculaire et Cellulaire LGMC, Université des sciences et de la technologie d'Oran Mohamed Boudiaf USTOMB
  • Faouzia ZEMANI FODIL Laboratoire de Génétique Moléculaire et Cellulaire LGMC, Université des sciences et de la technologie d'Oran Mohamed Boudiaf USTOMB
  • Elisabeth PETIT-TEIXEIRA Laboratoie Européen de recherche polyarthrite rhumatoide, GenHotel EA3886, Université d’Evry Val d’Essonne France
  • Abdallah BOUDJEMA Laboratoire de Génétique Moléculaire et Cellulaire LGMC, Université des sciences et de la technologie d'Oran Mohamed Boudiaf USTOMB
Keywords: rs3087243, CTLA4, Ankylosing Spondylitis, West of Algeria

Abstract

Background: Numerous studies have shown that polymorphism rs231775 of the CTLA4 gene is strongly implicated in the development of ankylosing spondylitis (AS). Other polymorphisms of this gene are candidates that may have an additional effect in susceptibility to AS. For the first time, we searched for the association of rs3087243 polymorphism located in the 3'UTR region of the CTLA4 gene with the development of SA in the Algerian population.

Methods: The study involved 200 subjects (80 AS patients recruited at the rheumatology service and 120 healthy individuals unrelated). Genotyping was performed by real-time PCR (Taqman®). Analysis of the results was carried out by IBM.SPSS.Statictis® software.

Results: The distribution of allele frequencies showed a significant association between the GG genotype of the polymorphism rs3087243 and AS risk (OR= 1.77 [0.98-3.21], p=0.004).

Conclusion: Our data would suggest that the 3'UTR region of the CTLA4 gene could have an impact on the development of SA in the West Algerian population. These results need to be confirmed on a larger sample.

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Published
2017-05-15
Section
Conference proceedings and abstracts